ACP1 (acid phosphatase 1)

2003-11-01  

Identity

HGNC
ACP1
LOCATION
2p25.3
LOCUSID
52
ALIAS
HAAP,LMW-PTP,LMWPTP

Other Information

Locus ID:

NCBI: 52
MIM: 171500
HGNC: 122
Ensembl: ENSG00000143727

Variants:

dbSNP: 52
ClinVar: 52
TCGA: ENSG00000143727
COSMIC: ACP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143727ENST00000272065P24666
ENSG00000143727ENST00000272067P24666
ENSG00000143727ENST00000405233F2Z2Q9
ENSG00000143727ENST00000405364F2Z2R9
ENSG00000143727ENST00000407983P24666
ENSG00000143727ENST00000407983A0A140VK37
ENSG00000143727ENST00000413140G5E9R5
ENSG00000143727ENST00000439645D3YTI2
ENSG00000143727ENST00000442386F2Z2R9
ENSG00000143727ENST00000453390F2Z2Q9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Thiamine metabolismKEGGko00730
Riboflavin metabolismKEGGko00740
Adherens junctionKEGGko04520
Thiamine metabolismKEGGhsa00730
Riboflavin metabolismKEGGhsa00740
Adherens junctionKEGGhsa04520
Metabolic pathwaysKEGGhsa01100

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445187OsteonecrosisDiseaseMultilinkAnnotationassociated25999454

References

Pubmed IDYearTitleCitations
346104712022Platelet-dependent signaling and Low Molecular Weight Protein Tyrosine Phosphatase expression promote aggressive phenotypic changes in gastrointestinal cancer cells.2
346104712022Platelet-dependent signaling and Low Molecular Weight Protein Tyrosine Phosphatase expression promote aggressive phenotypic changes in gastrointestinal cancer cells.2
330524342021Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks.5
330524342021Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks.5
320166962020LMWPTP modulates the antioxidant response and autophagy process in human chronic myeloid leukemia cells.5
322296872020Vemurafenib downmodulates aggressiveness mediators of colorectal cancer (CRC): Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP), Protein Tyrosine Phosphatase 1B (PTP1B) and Transforming Growth Factor β (TGFβ).3
320166962020LMWPTP modulates the antioxidant response and autophagy process in human chronic myeloid leukemia cells.5
322296872020Vemurafenib downmodulates aggressiveness mediators of colorectal cancer (CRC): Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP), Protein Tyrosine Phosphatase 1B (PTP1B) and Transforming Growth Factor β (TGFβ).3
303264762019Prediction of Time to Castration-Resistant Prostate Cancer Using Low-Molecular-Weight Protein Tyrosine Phosphatase Expression for Men with Metastatic Hormone-Naïve Prostate Cancer.2
303264762019Prediction of Time to Castration-Resistant Prostate Cancer Using Low-Molecular-Weight Protein Tyrosine Phosphatase Expression for Men with Metastatic Hormone-Naïve Prostate Cancer.2
295735682018Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy.7
295735682018Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy.7
286687162017Replication of rs300774, a genetic biomarker near ACP1, associated with suicide attempts in patients with schizophrenia: Relation to brain cholesterol biosynthesis.16
291874432017Total Knockdown of LMW-PTP in MDA-MB-231 Cells Reduces Osteoclastogenesis.1
286687162017Replication of rs300774, a genetic biomarker near ACP1, associated with suicide attempts in patients with schizophrenia: Relation to brain cholesterol biosynthesis.16

Citation

Dessen P

ACP1 (acid phosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/553/haematological-explorer/js/gene-fusions-explorer/