TAF12 (TATA-box binding protein associated factor 12)

2015-08-01 Affiliation

Identity

HGNC

TAF12

LOCATION

1p35.3

LOCUSID

6883

ALIAS

TAF2J,TAFII20

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6883
MIM: 600773
HGNC: 11545
Ensembl: ENSG00000120656

Variants:

dbSNP: 6883
ClinVar: 6883
TCGA: ENSG00000120656
COSMIC: TAF12

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000120656	ENST00000263974	Q16514
ENSG00000120656	ENST00000373824	Q16514

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Basal transcription factors	KEGG	ko03022
Basal transcription factors	KEGG	hsa03022
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Transcription of the HIV genome	REACTOME	R-HSA-167172
HIV Transcription Initiation	REACTOME	R-HSA-167161
RNA Polymerase II HIV Promoter Escape	REACTOME	R-HSA-167162
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Pre-transcription Events	REACTOME	R-HSA-674695
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	REACTOME	R-HSA-73779
RNA Polymerase II Transcription Initiation And Promoter Clearance	REACTOME	R-HSA-76042
RNA Polymerase II Transcription Initiation	REACTOME	R-HSA-75953
RNA Polymerase II Promoter Escape	REACTOME	R-HSA-73776
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
HATs acetylate histones	REACTOME	R-HSA-3214847
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
29316427	2018	A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia.	45
29316427	2018	A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia.	45
27551064	2016	Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer.	42
27551064	2016	Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer.	42
25965574	2015	Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.	43
25965574	2015	Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.	43
23426901	2013	Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.	6
23426901	2013	Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.	6
19635797	2009	TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes.	20
19635797	2009	TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes.	20
17268553	2007	Identification of novel functional TBP-binding sites and general factor repertoires.	60
17268553	2007	Identification of novel functional TBP-binding sites and general factor repertoires.	60
15601843	2005	Core promoter binding by histone-like TAF complexes.	34
15601843	2005	Core promoter binding by histone-like TAF complexes.	34
12237304	2002	Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20).	31

Citation

Dessen P

TAF12 (TATA-box binding protein associated factor 12)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55306