WAPL (WAPL cohesin release factor)

2015-08-01  

Identity

HGNC
WAPL
LOCATION
10q23.2
LOCUSID
23063
ALIAS
FOE,KIAA0261,WAPAL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23063
MIM: 610754
HGNC: 23293
Ensembl: ENSG00000062650

Variants:

dbSNP: 23063
ClinVar: 23063
TCGA: ENSG00000062650
COSMIC: WAPL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000062650ENST00000263070Q8WVX6
ENSG00000062650ENST00000298767Q7Z5K2
ENSG00000062650ENST00000372075F6QZY1
ENSG00000062650ENST00000618527Q7Z5K2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Establishment of Sister Chromatid CohesionREACTOMER-HSA-2468052
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Mitotic Telophase/CytokinesisREACTOMER-HSA-68884
Cohesin Loading onto ChromatinREACTOMER-HSA-2470946

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
351360672022A Mediator-cohesin axis controls heterochromatin domain formation.11
351360672022A Mediator-cohesin axis controls heterochromatin domain formation.11
339479622021WAPL induces cervical intraepithelial neoplasia modulated with estrogen signaling without HPV E6/E7.2
339479622021WAPL induces cervical intraepithelial neoplasia modulated with estrogen signaling without HPV E6/E7.2
320655812020ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin(STAG1) from WAPL.62
320843592020WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion.29
320655812020ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin(STAG1) from WAPL.62
320843592020WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion.29
306988082019Dysregulation of the cohesin subunit RAD21 by Hepatitis C virus mediates host-virus interactions.5
312049992019Absolute quantification of cohesin, CTCF and their regulators in human cells.43
315308112019Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection.26
306988082019Dysregulation of the cohesin subunit RAD21 by Hepatitis C virus mediates host-virus interactions.5
312049992019Absolute quantification of cohesin, CTCF and their regulators in human cells.43
315308112019Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection.26
291382362018A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion.26

Citation

Dessen P

WAPL (WAPL cohesin release factor)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55307