CTH (cystathionine gamma-lyase)

2015-08-01  

Identity

HGNC
CTH
LOCATION
1p31.1
LOCUSID
1491
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1491
MIM: 607657
HGNC: 2501
Ensembl: ENSG00000116761

Variants:

dbSNP: 1491
ClinVar: 1491
TCGA: ENSG00000116761
COSMIC: CTH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116761ENST00000346806P32929
ENSG00000116761ENST00000370938P32929
ENSG00000116761ENST00000411986P32929

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Selenocompound metabolismKEGGko00450
Glycine, serine and threonine metabolismKEGGhsa00260
Selenocompound metabolismKEGGhsa00450
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Cysteine biosynthesis, homocysteine + serine => cysteineKEGGhsa_M00338
Cysteine biosynthesis, homocysteine + serine => cysteineKEGGM00338
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Sulfur amino acid metabolismREACTOMER-HSA-1614635
Cysteine formation from homocysteineREACTOMER-HSA-1614603
Degradation of cysteine and homocysteineREACTOMER-HSA-1614558
Selenoamino acid metabolismREACTOMER-HSA-2408522
Metabolism of ingested SeMet, Sec, MeSec into H2SeREACTOMER-HSA-2408508

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166122646hemopoietic stem cell transplantDiseaseClinicalAnnotationassociatedPD27779248
PA448691busulfanChemicalClinicalAnnotationassociatedPD27779248
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD27779248

References

Pubmed IDYearTitleCitations
383886612024Identifying CTH and MAP1LC3B as ferroptosis biomarkers for prognostic indication in gastric cancer decoding.0
383886612024Identifying CTH and MAP1LC3B as ferroptosis biomarkers for prognostic indication in gastric cancer decoding.0
373009552023Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation.3
378003272023Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence.1
379227642023Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation.1
382389502023[Exploration of cystathionine β-synthase and cystathionine γ-lyase gene expression poor prognostic predictive value with the application of bioinformatics data mining in liver cancer].0
373009552023Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation.3
378003272023Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence.1
379227642023Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation.1
382389502023[Exploration of cystathionine β-synthase and cystathionine γ-lyase gene expression poor prognostic predictive value with the application of bioinformatics data mining in liver cancer].0
363103222022Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.0
365142192022KRAS G12D mutation eliminates reactive oxygen species through the Nrf2/CSE/H (2)S axis and contributes to pancreatic cancer growth.3
363103222022Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.0
365142192022KRAS G12D mutation eliminates reactive oxygen species through the Nrf2/CSE/H (2)S axis and contributes to pancreatic cancer growth.3
337601562021Hydrogen sulfide improves ox‑LDL‑induced expression levels of Lp‑PLA(2) in THP‑1 monocytes via the p38MAPK pathway.4

Citation

Dessen P

CTH (cystathionine gamma-lyase)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55338