IL34 (interleukin 34)

2015-08-01  

Identity

HGNC
IL34
LOCATION
16q22.1
LOCUSID
146433
ALIAS
C16orf77,IL-34
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 146433
MIM: 612081
HGNC: 28529
Ensembl: ENSG00000157368

Variants:

dbSNP: 146433
ClinVar: 146433
TCGA: ENSG00000157368
COSMIC: IL34

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157368ENST00000288098Q6ZMJ4
ENSG00000157368ENST00000288098A0A024QZ87
ENSG00000157368ENST00000429149Q6ZMJ4
ENSG00000157368ENST00000429149A0A024QZ87
ENSG00000157368ENST00000563721H3BPB7
ENSG00000157368ENST00000566361J3QQT3

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

References

Pubmed IDYearTitleCitations
381034072024Elevated serum IL-34 is correlated with disease severity in patients with biliary atresia following Kasai portoenterostomy.0
381668112024Cut-off value for interleukin-34 as an additional potential inflammatory biomarker for estimation of slow coronary flow risk.1
382180982024Longitudinal associations between serum IL-34 with severity and prognosis in community-acquired pneumonia patients.0
383673012024SAMHD1 dysfunction induces IL-34 expression via NF-κB p65 in neuronal SH-SY5Y cells.0
381034072024Elevated serum IL-34 is correlated with disease severity in patients with biliary atresia following Kasai portoenterostomy.0
381668112024Cut-off value for interleukin-34 as an additional potential inflammatory biomarker for estimation of slow coronary flow risk.1
382180982024Longitudinal associations between serum IL-34 with severity and prognosis in community-acquired pneumonia patients.0
383673012024SAMHD1 dysfunction induces IL-34 expression via NF-κB p65 in neuronal SH-SY5Y cells.0
343475762023Emerging roles of IL-34 in neurodegenerative and neurological infectious disease.0
365626872023Sp1 Controls the Basal Level of Interleukin-34 Transcription.0
371759322023BMP-2 Genome-Edited Human MSCs Protect against Cartilage Degeneration via Suppression of IL-34 in Collagen-Induced Arthritis.0
375337022023A mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by Oxaliplatin.1
375569432023Interleukin-34-NF-κB signaling aggravates myocardial ischemic/reperfusion injury by facilitating macrophage recruitment and polarization.2
379478922023Elevated circulating levels of IL-34 are strongly associated with osteoporosis.0
343475762023Emerging roles of IL-34 in neurodegenerative and neurological infectious disease.0

Citation

Dessen P

IL34 (interleukin 34)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55352