PRPS2 (phosphoribosyl pyrophosphate synthetase 2)

2015-08-01  

Identity

HGNC
PRPS2
LOCATION
Xp22.2
LOCUSID
5634
ALIAS
PRSII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5634
MIM: 311860
HGNC: 9465
Ensembl: ENSG00000101911

Variants:

dbSNP: 5634
ClinVar: 5634
TCGA: ENSG00000101911
COSMIC: PRPS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101911ENST00000380663A6NMS2
ENSG00000101911ENST00000380668P11908
ENSG00000101911ENST00000398491P11908
ENSG00000101911ENST00000398491A0A140VK41
ENSG00000101911ENST00000461630H7C540
ENSG00000101911ENST00000489404D3YTJ7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pentose phosphate pathwayKEGGko00030
Purine metabolismKEGGko00230
Pentose phosphate pathwayKEGGhsa00030
Purine metabolismKEGGhsa00230
Metabolic pathwaysKEGGhsa01100
PRPP biosynthesis, ribose 5P => PRPPKEGGhsa_M00005
PRPP biosynthesis, ribose 5P => PRPPKEGGM00005
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
5-Phosphoribose 1-diphosphate biosynthesisREACTOMER-HSA-73843

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
334931372021PRPS1-mediated purine biosynthesis is critical for pluripotent stem cell survival and stemness.2
335895312021Role of PRPS2 as a prognostic and therapeutic target in osteosarcoma.3
334931372021PRPS1-mediated purine biosynthesis is critical for pluripotent stem cell survival and stemness.2
335895312021Role of PRPS2 as a prognostic and therapeutic target in osteosarcoma.3
323916362020Molecular mechanism of c-Myc and PRPS1/2 against thiopurine resistance in Burkitt's lymphoma.5
333464152020[Expression of phosphoribosyl pyrophosphate synthase 2 in human testis tissue].0
323916362020Molecular mechanism of c-Myc and PRPS1/2 against thiopurine resistance in Burkitt's lymphoma.5
333464152020[Expression of phosphoribosyl pyrophosphate synthase 2 in human testis tissue].0
309089122019Targeted Quantitative Kinome Analysis Identifies PRPS2 as a Promoter for Colorectal Cancer Metastasis.13
309089122019Targeted Quantitative Kinome Analysis Identifies PRPS2 as a Promoter for Colorectal Cancer Metastasis.13
251494752015Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus.15
260048652015PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells.11
251494752015Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus.15
260048652015PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells.11
258166082014Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.4

Citation

Dessen P

PRPS2 (phosphoribosyl pyrophosphate synthetase 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55367