ADRA1D (adrenoceptor alpha 1D)

2015-08-01 Affiliation

Identity

HGNC

ADRA1D

LOCATION

20p13

LOCUSID

146

ALIAS

ADRA1,ADRA1A,ADRA1R,ALPHA1,DAR,dJ779E11.2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 146
MIM: 104219
HGNC: 280
Ensembl: ENSG00000171873

Variants:

dbSNP: 146
ClinVar: 146
TCGA: ENSG00000171873
COSMIC: ADRA1D

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000171873	ENST00000379453	P25100
ENSG00000171873	ENST00000379453	B0ZBE0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Adrenoceptors	REACTOME	R-HSA-390696
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
G alpha (12/13) signalling events	REACTOME	R-HSA-416482
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA164712344	Alpha-adrenoreceptor antagonists	Chemical	Pathway	associated
PA449396	dopamine	Chemical	Pathway	associated
PA449470	epinephrine	Chemical	Pathway	associated
PA450121	isoproterenol	Chemical	Pathway	associated
PA450431	methoxamine	Chemical	Pathway	associated
PA450649	norepinephrine	Chemical	Pathway	associated
PA450935	phenylephrine	Chemical	Pathway	associated

References

Pubmed ID	Year	Title	Citations
37571902	2023	Functional Involvement of ADRA1D in Cutaneous Melanoma Progression and Angiogenesis.	1
37571902	2023	Functional Involvement of ADRA1D in Cutaneous Melanoma Progression and Angiogenesis.	1
32085899	2020	Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α(1)-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays.	9
32350295	2020	N-glycosylation of α(1D)-adrenergic receptor N-terminal domain is required for correct trafficking, function, and biogenesis.	5
32085899	2020	Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α(1)-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays.	9
32350295	2020	N-glycosylation of α(1D)-adrenergic receptor N-terminal domain is required for correct trafficking, function, and biogenesis.	5
30419287	2019	Distinct phosphorylation sites/clusters in the carboxyl terminus regulate α(1D)-adrenergic receptor subcellular localization and signaling.	3
30419287	2019	Distinct phosphorylation sites/clusters in the carboxyl terminus regulate α(1D)-adrenergic receptor subcellular localization and signaling.	3
29089212	2018	Up-regulation of α(1)-adrenoceptors in burn and keloid scars.	7
29089212	2018	Up-regulation of α(1)-adrenoceptors in burn and keloid scars.	7
28862946	2017	α(1)-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells.	20
28862946	2017	α(1)-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells.	20
26621245	2016	A selective alpha1D-adrenoreceptor antagonist inhibits human prostate cancer cell proliferation and motility "in vitro".	4
26739946	2016	Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate.	2
27146292	2016	Carboxyl terminus-truncated α1D-adrenoceptors inhibit the ERK pathway.	1

Citation

Dessen P

ADRA1D (adrenoceptor alpha 1D)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55369