CERS4 (ceramide synthase 4)

2015-08-01  

Identity

HGNC
CERS4
LOCATION
19p13.2
LOCUSID
79603
ALIAS
LASS4,Trh1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79603
MIM: 615334
HGNC: 23747
Ensembl: ENSG00000090661

Variants:

dbSNP: 79603
ClinVar: 79603
TCGA: ENSG00000090661
COSMIC: CERS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090661ENST00000251363Q9HA82
ENSG00000090661ENST00000558268H0YLY3
ENSG00000090661ENST00000558331H0YKC9
ENSG00000090661ENST00000558877H0YNR6
ENSG00000090661ENST00000559336H0YN04
ENSG00000090661ENST00000559450Q9HA82
ENSG00000090661ENST00000560412H0YKS3
ENSG00000090661ENST00000561008H0YMY6
ENSG00000090661ENST00000561053H0YKR4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Ceramide biosynthesisKEGGM00094
Sphingosine biosynthesisKEGGM00099
Ceramide biosynthesisKEGGhsa_M00094
Sphingosine biosynthesisKEGGhsa_M00099
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377589312023Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer.1
378850132023Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer.2
377589312023Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer.1
378850132023Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer.2
297385502018Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium.9
297385502018Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium.9
268879522016Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.28
268879522016Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.28
257790242015Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers.10
257790242015Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers.10
235382982013The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.34
235382982013The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.34
217574282011Linkage and association of phospholipid transfer protein activity to LASS4.12
217574282011Linkage and association of phospholipid transfer protein activity to LASS4.12
200806502010Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.57

Citation

Dessen P

CERS4 (ceramide synthase 4)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55376/gene-explorer/favicon/css/lib/dataTables.bootstrap.min.css