CLIC3 (chloride intracellular channel 3)

2015-08-01  

Identity

HGNC
CLIC3
LOCATION
9q34.3
LOCUSID
9022
ALIAS
-

Other Information

Locus ID:

NCBI: 9022
MIM: 606533
HGNC: 2064
Ensembl: ENSG00000169583

Variants:

dbSNP: 9022
ClinVar: 9022
TCGA: ENSG00000169583
COSMIC: CLIC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169583ENST00000494426O95833

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381825712024CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression.0
381825712024CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression.0
352380652022Chloride intercellular channel 3 suppression-mediated macrophage polarization: a potential indicator of poor prognosis of hepatitis B virus-related acute-on-chronic liver failure.2
352380652022Chloride intercellular channel 3 suppression-mediated macrophage polarization: a potential indicator of poor prognosis of hepatitis B virus-related acute-on-chronic liver failure.2
347665852021Identification of chloride intracellular channels as prognostic factors correlated with immune infiltration in hepatocellular carcinoma using bioinformatics analysis.6
347665852021Identification of chloride intracellular channels as prognostic factors correlated with immune infiltration in hepatocellular carcinoma using bioinformatics analysis.6
320663742020Pathophysiological properties of CLIC3 chloride channel in human gastric cancer cells.2
320663742020Pathophysiological properties of CLIC3 chloride channel in human gastric cancer cells.2
281983602017Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.51
281983602017Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.51
264453682015Transcriptional over-expression of chloride intracellular channels 3 and 4 in malignant pleural mesothelioma.13
264453682015Transcriptional over-expression of chloride intracellular channels 3 and 4 in malignant pleural mesothelioma.13
250152902014CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer.58
250152902014CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer.58
227955782012Placental CLIC3 is increased in fetal growth restriction and pre-eclampsia affected human pregnancies.10

Citation

Dessen P

CLIC3 (chloride intracellular channel 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55383/css/lib/gene-explorer/js/lib/jquery-3.5.1.min.js