SCD5 (stearoyl-CoA desaturase 5)

2015-09-01  

Identity

HGNC
SCD5
LOCATION
4q21.22
LOCUSID
79966
ALIAS
ACOD4,DFNA79,FADS4,HSCD5,SCD2,SCD4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79966
MIM: 608370
HGNC: 21088
Ensembl: ENSG00000145284

Variants:

dbSNP: 79966
ClinVar: 79966
TCGA: ENSG00000145284
COSMIC: SCD5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145284ENST00000273908Q86SK9
ENSG00000145284ENST00000319540Q86SK9

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Biosynthesis of unsaturated fatty acidsKEGGko01040
PPAR signaling pathwayKEGGko03320
Biosynthesis of unsaturated fatty acidsKEGGhsa01040
PPAR signaling pathwayKEGGhsa03320
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370474902023Molecular Basis of Unequal Alternative Splicing of Human SCD5 and Its Alteration by Natural Genetic Variations.0
370474902023Molecular Basis of Unequal Alternative Splicing of Human SCD5 and Its Alteration by Natural Genetic Variations.0
360594592022SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4(+) T cells.0
362926692022A Single Nucleotide Polymorphism (rs3811792) Affecting Human SCD5 Promoter Activity Is Associated with Diabetes Mellitus.3
360594592022SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4(+) T cells.0
362926692022A Single Nucleotide Polymorphism (rs3811792) Affecting Human SCD5 Promoter Activity Is Associated with Diabetes Mellitus.3
330494042021Stearoyl-CoA desaturase 5 (SCD5), a Δ-9 fatty acyl desaturase in search of a function.21
339036142021SCD5 expression correlates with prognosis and response to neoadjuvant chemotherapy in breast cancer.8
330494042021Stearoyl-CoA desaturase 5 (SCD5), a Δ-9 fatty acyl desaturase in search of a function.21
339036142021SCD5 expression correlates with prognosis and response to neoadjuvant chemotherapy in breast cancer.8
319723692020Whole exome sequencing identifies SCD5 as a novel causative gene for autosomal dominant nonsyndromic deafness.5
319723692020Whole exome sequencing identifies SCD5 as a novel causative gene for autosomal dominant nonsyndromic deafness.5
301680962018Polymorphisms in the 3'-UTR of SCD5 gene are associated with hepatocellular carcinoma in Korean population.2
301680962018Polymorphisms in the 3'-UTR of SCD5 gene are associated with hepatocellular carcinoma in Korean population.2
258022342015SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.25

Citation

Dessen P

SCD5 (stearoyl-CoA desaturase 5)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55387