GPR37 (G protein-coupled receptor 37)

2015-09-01  

Identity

HGNC
GPR37
LOCATION
7q31.33
LOCUSID
2861
ALIAS
EDNRBL,PAELR,hET(B)R-LP

Other Information

Locus ID:

NCBI: 2861
MIM: 602583
HGNC: 4494
Ensembl: ENSG00000170775

Variants:

dbSNP: 2861
ClinVar: 2861
TCGA: ENSG00000170775
COSMIC: GPR37

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170775ENST00000303921O15354

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Parkinson's diseaseKEGGhsa05012
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377326322023Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer.2
377492292023GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.6
377326322023Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer.2
377492292023GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.6
359341932022GPR37 promotes cancer growth by binding to CDK6 and represents a new theranostic target in lung adenocarcinoma.10
359341932022GPR37 promotes cancer growth by binding to CDK6 and represents a new theranostic target in lung adenocarcinoma.10
336371322021Ecto-GPR37: a potential biomarker for Parkinson's disease.10
336371322021Ecto-GPR37: a potential biomarker for Parkinson's disease.10
304232892019GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells.10
304232892019GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells.10
294966072018A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease.6
299733252018[Up-regulation of GPR37 promotes the proliferation of human glioma U251 cells].3
294966072018A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease.6
299733252018[Up-regulation of GPR37 promotes the proliferation of human glioma U251 cells].3
270360492016REG4 promotes peritoneal metastasis of gastric cancer through GPR37.32

Citation

Dessen P

GPR37 (G protein-coupled receptor 37)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55392/js/web-card-_common.js