NLRX1 (NLR family member X1)

2015-09-01  

Identity

HGNC
NLRX1
LOCATION
11q23.3
LOCUSID
79671
ALIAS
CLR11.3,DLNB26,NOD26,NOD5,NOD9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79671
MIM: 611947
HGNC: 29890
Ensembl: ENSG00000160703

Variants:

dbSNP: 79671
ClinVar: 79671
TCGA: ENSG00000160703
COSMIC: NLRX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160703ENST00000292199Q86UT6
ENSG00000160703ENST00000409109Q86UT6
ENSG00000160703ENST00000409265Q86UT6
ENSG00000160703ENST00000409991Q86UT6
ENSG00000160703ENST00000422249C9JLK8
ENSG00000160703ENST00000449394C9JQE9
ENSG00000160703ENST00000454811C9J0R6
ENSG00000160703ENST00000525863Q86UT6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375741632024NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy.3
386834552024NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression.0
388910452024NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light-Chain Kinase (ERK/MLCK) Pathway.0
375741632024NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy.3
386834552024NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression.0
388910452024NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light-Chain Kinase (ERK/MLCK) Pathway.0
366178382023NLRX1 increases human retinal pigment epithelial autophagy and reduces H(2)O(2)-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation.3
366178382023NLRX1 increases human retinal pigment epithelial autophagy and reduces H(2)O(2)-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation.3
361949712022The regulatory role of NLRX1 in innate immunity and human disease.6
361949712022The regulatory role of NLRX1 in innate immunity and human disease.6
332537162021MicroRNA-195 suppresses enterovirus A71-induced pyroptosis in human neuroblastoma cells through targeting NLRX1.6
335256712021Focusing on the Cell Type Specific Regulatory Actions of NLRX1.15
336869562021Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury.18
339715592021Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling activation.5
347901952021Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific.2

Citation

Dessen P

NLRX1 (NLR family member X1)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55406