SHMT2 (serine hydroxymethyltransferase 2)

2015-10-01  

Identity

HGNC
SHMT2
LOCATION
12q13.3
LOCUSID
6472
ALIAS
GLYA,HEL-S-51e,NEDCASB,SHMT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6472
MIM: 138450
HGNC: 10852
Ensembl: ENSG00000182199

Variants:

dbSNP: 6472
ClinVar: 6472
TCGA: ENSG00000182199
COSMIC: SHMT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182199ENST00000328923P34897
ENSG00000182199ENST00000328923V9HW06
ENSG00000182199ENST00000414700P34897
ENSG00000182199ENST00000414700A0A024RB99
ENSG00000182199ENST00000449049P34897
ENSG00000182199ENST00000449049A0A024RB99
ENSG00000182199ENST00000553474P34897
ENSG00000182199ENST00000553474A0A024RB99
ENSG00000182199ENST00000553529G3V3Y8
ENSG00000182199ENST00000553837G3V540
ENSG00000182199ENST00000554310G3V2W0
ENSG00000182199ENST00000554604G3V540
ENSG00000182199ENST00000554975G3V5L0
ENSG00000182199ENST00000555116G3V2Y1
ENSG00000182199ENST00000555563G3V3C6
ENSG00000182199ENST00000555634G3V2Y4
ENSG00000182199ENST00000555773G3V4T0
ENSG00000182199ENST00000555774G3V2Y1
ENSG00000182199ENST00000556689G3V4W5
ENSG00000182199ENST00000556737G3V3Y8
ENSG00000182199ENST00000556825G3V3C6
ENSG00000182199ENST00000557269G3V2D2
ENSG00000182199ENST00000557348G3V2Y1
ENSG00000182199ENST00000557427G3V4X0
ENSG00000182199ENST00000557433G3V2E4
ENSG00000182199ENST00000557487P34897
ENSG00000182199ENST00000557529H0YIZ0
ENSG00000182199ENST00000557703G3V241

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Glyoxylate and dicarboxylate metabolismKEGGko00630
One carbon pool by folateKEGGko00670
Glycine, serine and threonine metabolismKEGGhsa00260
Glyoxylate and dicarboxylate metabolismKEGGhsa00630
One carbon pool by folateKEGGhsa00670
Metabolic pathwaysKEGGhsa01100
C1-unit interconversion, eukaryotesKEGGhsa_M00141
C1-unit interconversion, eukaryotesKEGGM00141
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Metabolism of folate and pterinesREACTOMER-HSA-196757
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379837222024YTHDF1 enhances stemness and chemoresistance in triple-negative breast cancer cells by upregulating SIAH2.2
381881432024The expression and clinical significance of serine hydroxymethyltransferase2 in gastric cancer.0
384601552024Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma.1
379837222024YTHDF1 enhances stemness and chemoresistance in triple-negative breast cancer cells by upregulating SIAH2.2
381881432024The expression and clinical significance of serine hydroxymethyltransferase2 in gastric cancer.0
384601552024Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma.1
368063132023Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.4
369173252023MiR-24-1-5p Hinders Malignant Phenotypes of Clear Cell Renal Cell Carcinoma by Targeting SHOX2.0
371083122023SHMT2 Promotes Gastric Cancer Development through Regulation of HIF1α/VEGF/STAT3 Signaling.2
377421292023NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2.0
368063132023Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.4
369173252023MiR-24-1-5p Hinders Malignant Phenotypes of Clear Cell Renal Cell Carcinoma by Targeting SHOX2.0
371083122023SHMT2 Promotes Gastric Cancer Development through Regulation of HIF1α/VEGF/STAT3 Signaling.2
377421292023NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2.0
346240792022SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.16

Citation

Dessen P

SHMT2 (serine hydroxymethyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55419