OTULIN (OTU deubiquitinase with linear linkage specificity)

2015-10-01  

Identity

HGNC
OTULIN
LOCATION
5p15.2
LOCUSID
90268
ALIAS
AIPDS,FAM105B,GUM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 90268
MIM: 615712
HGNC: 25118
Ensembl: ENSG00000154124

Variants:

dbSNP: 90268
ClinVar: 90268
TCGA: ENSG00000154124
COSMIC: OTULIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154124ENST00000284274Q96BN8
ENSG00000154124ENST00000503023D6RD57
ENSG00000154124ENST00000506417H0Y9T0
ENSG00000154124ENST00000514913H0Y8S4

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
Regulation of TNFR1 signalingREACTOMER-HSA-5357905
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385783072024OTULIN Haploinsufficiency Causes Hyperinflammatory Responses to Infectious and Non-Infectious Triggers.0
385783072024OTULIN Haploinsufficiency Causes Hyperinflammatory Responses to Infectious and Non-Infectious Triggers.0
375890752023An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.1
380628202023Integrated Single-Cell and Transcriptome Sequencing Analyses Develop a Ubiquitination-Associated Signature in Gastric Cancer and Identified OTULIN as a Novel Biomarker.1
375890752023An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.1
380628202023Integrated Single-Cell and Transcriptome Sequencing Analyses Develop a Ubiquitination-Associated Signature in Gastric Cancer and Identified OTULIN as a Novel Biomarker.1
355875112022Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.19
359396952022Reciprocal interplay between OTULIN-LUBAC determines genotoxic and inflammatory NF-κB signal responses.1
355875112022Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.19
359396952022Reciprocal interplay between OTULIN-LUBAC determines genotoxic and inflammatory NF-κB signal responses.1
325432672021LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.25
325432672021LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.25
322312462020OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer.38
327700222020ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers.28
322312462020OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer.38

Citation

Dessen P

OTULIN (OTU deubiquitinase with linear linkage specificity)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55461