CENPC (centromere protein C)

2015-10-01  

Identity

HGNC
CENPC
LOCATION
4q13.2
LOCUSID
1060
ALIAS
CENP-C,CENPC1,MIF2,hcp-4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1060
MIM: 117141
HGNC: 1854
Ensembl: ENSG00000145241

Variants:

dbSNP: 1060
ClinVar: 1060
TCGA: ENSG00000145241
COSMIC: CENPC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145241ENST00000273853Q03188
ENSG00000145241ENST00000506882Q03188
ENSG00000145241ENST00000513216H0Y8J2
ENSG00000145241ENST00000515140H0Y9W1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

References

Pubmed IDYearTitleCitations
330651122021The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?6
330651122021The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?6
329455642020A genetic memory initiates the epigenetic loop necessary to preserve centromere position.16
329455642020A genetic memory initiates the epigenetic loop necessary to preserve centromere position.16
314754392019CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail.32
316767162019CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization.29
314754392019CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail.32
316767162019CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization.29
293435522018Constitutive centromere-associated network contacts confer differential stability on CENP-A nucleosomes in vitro and in the cell.18
293435522018Constitutive centromere-associated network contacts confer differential stability on CENP-A nucleosomes in vitro and in the cell.18
281677792017Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T.57
287875902017Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C.94
292807352017Decoding the centromeric nucleosome through CENP-N.62
281677792017Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T.57
287875902017Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C.94

Citation

Dessen P

CENPC (centromere protein C)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55465/deep-insight-explorer/js/js/web-card-_common.js