ACP5 (acid phosphatase 5, tartrate resistant)

2003-11-01  

Identity

HGNC
ACP5
LOCATION
19p13.2
LOCUSID
54
ALIAS
HPAP,TRACP5a,TRACP5b,TRAP,TrATPase
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54
MIM: 171640
HGNC: 124
Ensembl: ENSG00000102575

Variants:

dbSNP: 54
ClinVar: 54
TCGA: ENSG00000102575
COSMIC: ACP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102575ENST00000218758P13686
ENSG00000102575ENST00000218758A0A024R7F8
ENSG00000102575ENST00000412435P13686
ENSG00000102575ENST00000412435A0A024R7F8
ENSG00000102575ENST00000589792K7ESF2
ENSG00000102575ENST00000590420K7ES19
ENSG00000102575ENST00000590832K7EJD9
ENSG00000102575ENST00000591319K7EIP0
ENSG00000102575ENST00000592828P13686
ENSG00000102575ENST00000648477P13686
ENSG00000102575ENST00000648477A0A024R7F8
ENSG00000102575ENST00000649386A0A3B3IS75

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Riboflavin metabolismKEGGko00740
Riboflavin metabolismKEGGhsa00740
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolic pathwaysKEGGhsa01100
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin B2 (riboflavin) metabolismREACTOMER-HSA-196843

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373825512024Spondyloenchondrodysplasia with immune dysregulation related to ACP5. A report of 4 cases.2
388794882024Inhibition of tartrate-resistant acid phosphatase 5 can prevent cardiac fibrosis after myocardial infarction.0
373825512024Spondyloenchondrodysplasia with immune dysregulation related to ACP5. A report of 4 cases.2
388794882024Inhibition of tartrate-resistant acid phosphatase 5 can prevent cardiac fibrosis after myocardial infarction.0
366370402023Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.1
370105872023Spondyloenchondrodysplasia in five new patients: identification of three novel ACP5 variants with variable neurological presentations.2
366370402023Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.1
370105872023Spondyloenchondrodysplasia in five new patients: identification of three novel ACP5 variants with variable neurological presentations.2
350132202022Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.14
351024442022The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis.5
350132202022Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.14
351024442022The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis.5
335638752021Expression of tartrate-resistant acid phosphatase and cathepsin K during osteoclast differentiation in developing mouse mandibles.6
335638752021Expression of tartrate-resistant acid phosphatase and cathepsin K during osteoclast differentiation in developing mouse mandibles.6
315317622020Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels.1

Citation

Dessen P

ACP5 (acid phosphatase 5, tartrate resistant)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/555