LPCAT2 (lysophosphatidylcholine acyltransferase 2)

2015-11-01  

Identity

HGNC
LOCATION
16q12.2
LOCUSID
ALIAS
AGPAT11,AYTL1,LysoPAFAT
FUSION GENES

Other Information

Locus ID:

NCBI: 54947
MIM: 612040
HGNC: 26032
Ensembl: ENSG00000087253

Variants:

dbSNP: 54947
ClinVar: 54947
TCGA: ENSG00000087253
COSMIC: LPCAT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087253ENST00000262134Q7L5N7
ENSG00000087253ENST00000564084H3BU68

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodelling of PCREACTOMER-HSA-1482788

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386052142024LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis.2
386052142024LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis.2
325873242020Lysophosphatidylcholine acyltransferase 2 (LPCAT2) co-localises with TLR4 and regulates macrophage inflammatory gene expression in response to LPS.17
325873242020Lysophosphatidylcholine acyltransferase 2 (LPCAT2) co-localises with TLR4 and regulates macrophage inflammatory gene expression in response to LPS.17
254119672014A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes.46
254119672014A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes.46
238441242013Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses.11
238441242013Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses.11
210480312011Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.5
214985052011Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine.75
210480312011Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.5
214985052011Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine.75
203638362010Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers.27
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15

Citation

Dessen P

LPCAT2 (lysophosphatidylcholine acyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-11-01

Online version: http://atlasgeneticsoncology.org/gene/55528/js/favicon/favicon-32x32.png