BORA (BORA aurora kinase A activator)

2016-01-01  

Identity

HGNC
BORA
LOCATION
13q21.33
LOCUSID
79866
ALIAS
C13orf34
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79866
MIM: 610510
HGNC: 24724
Ensembl: ENSG00000136122

Variants:

dbSNP: 79866
ClinVar: 79866
TCGA: ENSG00000136122
COSMIC: BORA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136122ENST00000377814H3BLY2
ENSG00000136122ENST00000390667Q6PGQ7
ENSG00000136122ENST00000613797A0A087WV86
ENSG00000136122ENST00000618209A0A087WVC9
ENSG00000136122ENST00000651376A0A494C1R8
ENSG00000136122ENST00000651477Q6PGQ7
ENSG00000136122ENST00000652266Q6PGQ7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
337719962021Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.12
342876492021Aurora A kinase activation: Different means to different ends.11
337719962021Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.12
342876492021Aurora A kinase activation: Different means to different ends.11
284022762017Cell cycle protein Bora serves as a novel poor prognostic factor in multiple adenocarcinomas.7
284022762017Cell cycle protein Bora serves as a novel poor prognostic factor in multiple adenocarcinomas.7
270684772016Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells.28
278318272016Mitotic entry: The interplay between Cdk1, Plk1 and Bora.21
270684772016Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells.28
278318272016Mitotic entry: The interplay between Cdk1, Plk1 and Bora.21
257424932015Bora downregulation results in radioresistance by promoting repair of double strand breaks.5
257424932015Bora downregulation results in radioresistance by promoting repair of double strand breaks.5
243383642014Bora and Aurora-A continue to activate Plk1 in mitosis.58
243383642014Bora and Aurora-A continue to activate Plk1 in mitosis.58
235927822013Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein.22

Citation

Dessen P

BORA (BORA aurora kinase A activator)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/55602