NECTIN2 (nectin cell adhesion molecule 2)

2015-03-01  

Identity

HGNC
NECTIN2
LOCATION
19q13.32
LOCUSID
5819
ALIAS
CD112,HVEB,PRR2,PVRL2,PVRR2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5819
MIM: 600798
HGNC: 9707
Ensembl: ENSG00000130202

Variants:

dbSNP: 5819
ClinVar: 5819
TCGA: ENSG00000130202
COSMIC: NECTIN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130202ENST00000252483Q92692
ENSG00000130202ENST00000252485Q92692
ENSG00000130202ENST00000585601K7EK87
ENSG00000130202ENST00000591581K7EKE8
ENSG00000130202ENST00000592018K7ERL3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Adherens junctionKEGGko04520
Cell adhesion molecules (CAMs)KEGGhsa04514
Adherens junctionKEGGhsa04520
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Nectin/Necl trans heterodimerizationREACTOMER-HSA-420597

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384089612024The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults.1
384743882024CD112 Supports Lymphatic Migration of Human Dermal Dendritic Cells.0
385884102024PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways.0
385922132024Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition.0
384089612024The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults.1
384743882024CD112 Supports Lymphatic Migration of Human Dermal Dendritic Cells.0
385884102024PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways.0
385922132024Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition.0
369162962023Nectin2 influences cell apoptosis by regulating ANXA2 expression in neuroblastoma.2
371085782023Metabolic Overlap between Alzheimer's Disease and Metabolic Syndrome Identifies the PVRL2 Gene as a New Modulator of Diabetic Dyslipidemia.2
373789492023Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia.0
373832342023Single-cell RNA sequencing highlights the role of PVR/PVRL2 in the immunosuppressive tumour microenvironment in hepatocellular carcinoma.2
369162962023Nectin2 influences cell apoptosis by regulating ANXA2 expression in neuroblastoma.2
371085782023Metabolic Overlap between Alzheimer's Disease and Metabolic Syndrome Identifies the PVRL2 Gene as a New Modulator of Diabetic Dyslipidemia.2
373789492023Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia.0

Citation

Dessen P

NECTIN2 (nectin cell adhesion molecule 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55629