NECTIN3 (nectin cell adhesion molecule 3)

2015-03-01  

Identity

HGNC
NECTIN3
LOCATION
3q13.13
LOCUSID
25945
ALIAS
CD113,CDW113,NECTIN-3,PPR3,PRR3,PVRL3,PVRR3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25945
MIM: 607147
HGNC: 17664
Ensembl: ENSG00000177707

Variants:

dbSNP: 25945
ClinVar: 25945
TCGA: ENSG00000177707
COSMIC: NECTIN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177707ENST00000319792Q9NQS3
ENSG00000177707ENST00000461477C9J795
ENSG00000177707ENST00000481766C9JMW3
ENSG00000177707ENST00000485303Q9NQS3
ENSG00000177707ENST00000485506H7C5G5
ENSG00000177707ENST00000486596H7C4L0
ENSG00000177707ENST00000491525C9IZE6
ENSG00000177707ENST00000493615Q9NQS3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Adherens junctionKEGGko04520
Cell adhesion molecules (CAMs)KEGGhsa04514
Adherens junctionKEGGhsa04520
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Nectin/Necl trans heterodimerizationREACTOMER-HSA-420597

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
318553172020Loss of nectin-3 expression as a marker of tumor aggressiveness in pancreatic neuroendocrine tumor.6
318553172020Loss of nectin-3 expression as a marker of tumor aggressiveness in pancreatic neuroendocrine tumor.6
304690782019Nectin-3 is a new biomarker that mediates the upregulation of MMP2 and MMP9 in ovarian cancer cells.14
304690782019Nectin-3 is a new biomarker that mediates the upregulation of MMP2 and MMP9 in ovarian cancer cells.14
286892292017Detection of candidate nectin gene mutations in infertile men with severe teratospermia.3
286892292017Detection of candidate nectin gene mutations in infertile men with severe teratospermia.3
256907532015Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis.13
260385602015Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity.91
266020832015Binding and entry of Clostridium difficile toxin B is mediated by multiple domains.20
256907532015Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis.13
260385602015Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity.91
266020832015Binding and entry of Clostridium difficile toxin B is mediated by multiple domains.20
241162282013Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration.16
243861102013The expression of the Nectin complex in human breast cancer and the role of Nectin-3 in the control of tight junctions during metastasis.17
241162282013Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration.16

Citation

Dessen P

NECTIN3 (nectin cell adhesion molecule 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55656/js/lib/tumors-explorer/haematological-explorer/