NECTIN3 (nectin cell adhesion molecule 3)

2015-03-01  

Identity

HGNC
LOCATION
3q13.13
LOCUSID
ALIAS
CD113,CDW113,NECTIN-3,PPR3,PRR3,PVRL3,PVRR3
FUSION GENES

Other Information

Locus ID:

NCBI: 25945
MIM: 607147
HGNC: 17664
Ensembl: ENSG00000177707

Variants:

dbSNP: 25945
ClinVar: 25945
TCGA: ENSG00000177707
COSMIC: NECTIN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177707ENST00000319792Q9NQS3
ENSG00000177707ENST00000461477C9J795
ENSG00000177707ENST00000481766C9JMW3
ENSG00000177707ENST00000485303Q9NQS3
ENSG00000177707ENST00000485506H7C5G5
ENSG00000177707ENST00000486596H7C4L0
ENSG00000177707ENST00000491525C9IZE6
ENSG00000177707ENST00000493615Q9NQS3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Adherens junctionKEGGko04520
Cell adhesion molecules (CAMs)KEGGhsa04514
Adherens junctionKEGGhsa04520
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Nectin/Necl trans heterodimerizationREACTOMER-HSA-420597

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
318553172020Loss of nectin-3 expression as a marker of tumor aggressiveness in pancreatic neuroendocrine tumor.6
318553172020Loss of nectin-3 expression as a marker of tumor aggressiveness in pancreatic neuroendocrine tumor.6
304690782019Nectin-3 is a new biomarker that mediates the upregulation of MMP2 and MMP9 in ovarian cancer cells.14
304690782019Nectin-3 is a new biomarker that mediates the upregulation of MMP2 and MMP9 in ovarian cancer cells.14
286892292017Detection of candidate nectin gene mutations in infertile men with severe teratospermia.3
286892292017Detection of candidate nectin gene mutations in infertile men with severe teratospermia.3
256907532015Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis.13
260385602015Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity.91
266020832015Binding and entry of Clostridium difficile toxin B is mediated by multiple domains.20
256907532015Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis.13
260385602015Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity.91
266020832015Binding and entry of Clostridium difficile toxin B is mediated by multiple domains.20
241162282013Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration.16
243861102013The expression of the Nectin complex in human breast cancer and the role of Nectin-3 in the control of tight junctions during metastasis.17
241162282013Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration.16

Citation

Dessen P

NECTIN3 (nectin cell adhesion molecule 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55656/js/lib/tumors-explorer/img/logo-atlas-4.svg