TOLLIP (toll interacting protein)

2016-04-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
IL-1RAcPIP
FUSION GENES

Other Information

Locus ID:

NCBI: 54472
MIM: 606277
HGNC: 16476
Ensembl: ENSG00000078902

Variants:

dbSNP: 54472
ClinVar: 54472
TCGA: ENSG00000078902
COSMIC: TOLLIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078902ENST00000263646E7EN89
ENSG00000078902ENST00000317204Q9H0E2
ENSG00000078902ENST00000317204Q6FIE9
ENSG00000078902ENST00000525159F2Z2Y8
ENSG00000078902ENST00000527886Q9H0E2
ENSG00000078902ENST00000527938E9PNS3
ENSG00000078902ENST00000530506E9PP67
ENSG00000078902ENST00000530541E9PQ25

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445468Pulmonary FibrosisDiseaseClinicalAnnotationassociatedPD
PA448033acetylcysteineChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
376443702023Toll-interacting protein may affect doxorubicin resistance in hepatocellular carcinoma cell lines.0
381247532023Tollip deficiency exaggerates airway type 2 inflammation in mice exposed to allergen and influenza A virus: role of the ATP/IL-33 signaling axis.1
376443702023Toll-interacting protein may affect doxorubicin resistance in hepatocellular carcinoma cell lines.0
381247532023Tollip deficiency exaggerates airway type 2 inflammation in mice exposed to allergen and influenza A virus: role of the ATP/IL-33 signaling axis.1
344194272022Alternative Gene Expression by TOLLIP Variant Is Associated With Lung Function in Chronic Hypersensitivity Pneumonitis.2
351646502022Somatostatin attenuates intestinal epithelial barrier injury during acute intestinal ischemia-reperfusion through Tollip/Myeloiddifferentiationfactor 88/Nuclear factor kappa-B signaling.1
358036952022TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis.4
364990302022TOLLIP Protein Expression Predicts Unfavorable Outcome in Renal Cell Carcinoma.1
344194272022Alternative Gene Expression by TOLLIP Variant Is Associated With Lung Function in Chronic Hypersensitivity Pneumonitis.2
351646502022Somatostatin attenuates intestinal epithelial barrier injury during acute intestinal ischemia-reperfusion through Tollip/Myeloiddifferentiationfactor 88/Nuclear factor kappa-B signaling.1
358036952022TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis.4
364990302022TOLLIP Protein Expression Predicts Unfavorable Outcome in Renal Cell Carcinoma.1
331285792021Toll-interacting protein impacts on inflammation, autophagy, and vacuole trafficking in human disease.11
332339202021Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle.7
336399952021Potential clinical utility of MUC5B und TOLLIP single nucleotide polymorphisms (SNPs) in the management of patients with IPF.20

Citation

Dessen P

TOLLIP (toll interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55714/meetings/gene-fusions-explorer/css/card-gene.css