SLC39A5 (solute carrier family 39 member 5)

2016-05-01 Affiliation

Identity

HGNC

SLC39A5

LOCATION

12q13.3

LOCUSID

283375

ALIAS

LZT-Hs7,MYP24,ZIP5

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 283375
MIM: 608730
HGNC: 20502
Ensembl: ENSG00000139540

Variants:

dbSNP: 283375
ClinVar: 283375
TCGA: ENSG00000139540
COSMIC: SLC39A5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000139540	ENST00000266980	Q6ZMH5
ENSG00000139540	ENST00000266980	A0A024RB24
ENSG00000139540	ENST00000417965	C9JPS6
ENSG00000139540	ENST00000419753	C9JPS5
ENSG00000139540	ENST00000424625	C9JIB2
ENSG00000139540	ENST00000436633	C9JB28
ENSG00000139540	ENST00000437277	C9JVC6
ENSG00000139540	ENST00000454355	Q6ZMH5
ENSG00000139540	ENST00000454355	A0A024RB24

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Metal ion SLC transporters	REACTOME	R-HSA-425410
Zinc transporters	REACTOME	R-HSA-435354
Zinc influx into cells by the SLC39 gene family	REACTOME	R-HSA-442380

References

Pubmed ID	Year	Title	Citations
36454509	2023	Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity.	4
36454509	2023	Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity.	4
34252710	2021	SLC39A5 promotes lung adenocarcinoma cell proliferation by activating PI3K/AKT signaling.	2
34270706	2021	Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5.	1
34302427	2021	SLC39A5 dysfunction impairs extracellular matrix synthesis in high myopia pathogenesis.	5
34252710	2021	SLC39A5 promotes lung adenocarcinoma cell proliferation by activating PI3K/AKT signaling.	2
34270706	2021	Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5.	1
34302427	2021	SLC39A5 dysfunction impairs extracellular matrix synthesis in high myopia pathogenesis.	5
27458102	2016	Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits Esophageal Cancer Growth In Vivo.	6
27458102	2016	Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits Esophageal Cancer Growth In Vivo.	6
26133979	2015	Knockdown of zinc transporter ZIP5 (SLC39A5) expression significantly inhibits human esophageal cancer progression.	18
26133979	2015	Knockdown of zinc transporter ZIP5 (SLC39A5) expression significantly inhibits human esophageal cancer progression.	18
25525168	2014	Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing.	47
25525168	2014	Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing.	47
15322118	2004	The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.	54

Citation

Dessen P

SLC39A5 (solute carrier family 39 member 5)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55757