BLVRB (biliverdin reductase B)

2016-08-01  

Identity

HGNC
BLVRB
LOCATION
19q13.2
LOCUSID
645
ALIAS
BVRB,FLR,HEL-S-10,SDR43U1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 645
MIM: 600941
HGNC: 1063
Ensembl: ENSG00000090013

Variants:

dbSNP: 645
ClinVar: 645
TCGA: ENSG00000090013
COSMIC: BLVRB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090013ENST00000263368P30043
ENSG00000090013ENST00000263368V9HWI1
ENSG00000090013ENST00000595483M0R192
ENSG00000090013ENST00000597870M0QZL1
ENSG00000090013ENST00000643519A0A2R8YEP4
ENSG00000090013ENST00000643596A0A2R8Y7Y9

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Riboflavin metabolismKEGGko00740
Porphyrin and chlorophyll metabolismKEGGko00860
Riboflavin metabolismKEGGhsa00740
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of porphyrinsREACTOMER-HSA-189445
Heme degradationREACTOMER-HSA-189483

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA450457methylene blueChemicalLabelAnnotation, Pathwayassociated23913015

References

Pubmed IDYearTitleCitations
373714622023Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis.0
373714622023Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis.0
322468272020Structure, dynamics and function of the evolutionarily changing biliverdin reductase B family.9
322468272020Structure, dynamics and function of the evolutionarily changing biliverdin reductase B family.9
294871332018In silico and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency.4
295002322018Heme degradation enzyme biliverdin IXβ reductase is required for stem cell glutamine metabolism.7
294871332018In silico and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency.4
295002322018Heme degradation enzyme biliverdin IXβ reductase is required for stem cell glutamine metabolism.7
267081472016MicroRNA-127-5p targets the biliverdin reductase B/nuclear factor-κB pathway to suppress cell growth in hepatocellular carcinoma cells.34
272077952016BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans.18
267081472016MicroRNA-127-5p targets the biliverdin reductase B/nuclear factor-κB pathway to suppress cell growth in hepatocellular carcinoma cells.34
272077952016BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans.18
257263842015Biliverdin reductase isozymes in metabolism.70
257263842015Biliverdin reductase isozymes in metabolism.70
182412012008Computational and experimental studies on the catalytic mechanism of biliverdin-IXbeta reductase.14

Citation

Dessen P

BLVRB (biliverdin reductase B)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55876/gene-explorer/tumors-explorer/gene-explorer/