TREM2 (triggering receptor expressed on myeloid cells 2)

2016-08-01  

Identity

HGNC
TREM2
LOCATION
6p21.1
LOCUSID
54209
ALIAS
PLOSL2,TREM-2,Trem2a,Trem2b,Trem2c

Other Information

Locus ID:

NCBI: 54209
MIM: 605086
HGNC: 17761
Ensembl: ENSG00000095970

Variants:

dbSNP: 54209
ClinVar: 54209
TCGA: ENSG00000095970
COSMIC: TREM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095970ENST00000338469Q9NZC2
ENSG00000095970ENST00000373113Q9NZC2
ENSG00000095970ENST00000373113Q5TCX1
ENSG00000095970ENST00000373122Q9NZC2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364031502024TREM-2: friend or foe in infectious diseases?2
374984312024TREM-2 Drives Development of Multiple Sclerosis by Promoting Pathogenic Th17 Polarization.0
377404982024Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders.3
379411342024TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas.3
380121192024Effect of triggering receptor expressed on myeloid cells 2-associated alterations on lipid metabolism in macrophages in the development of non-alcoholic fatty liver disease.0
382371572024Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma.4
382446512024TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges.0
383263982024TREM2 mediates phagocytosis in glioblastoma.0
385056122024Dynamic pathological analysis reveals a protective role against skin fibrosis for TREM2-dependent macrophages.0
385923042024Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer's Disease and Reflect Central Neuroinflammation.0
386090372024Myeloid Trem2 ameliorates the progression of metabolic dysfunction-associated steatotic liver disease by regulating macrophage pyroptosis and inflammation resolution.0
386139442024SHIP inhibition mediates select TREM2-induced microglial functions.0
364031502024TREM-2: friend or foe in infectious diseases?2
374984312024TREM-2 Drives Development of Multiple Sclerosis by Promoting Pathogenic Th17 Polarization.0
377404982024Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders.3

Citation

Dessen P

TREM2 (triggering receptor expressed on myeloid cells 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55900