CENPS (centromere protein S)

2016-09-01  

Identity

HGNC
CENPS
LOCATION
1p36.22
LOCUSID
378708
ALIAS
APITD1,CENP-S,FAAP16,MHF1

Other Information

Locus ID:

NCBI: 378708
MIM: 609130
HGNC: 23163
Ensembl: ENSG00000175279

Variants:

dbSNP: 378708
ClinVar: 378708
TCGA: ENSG00000175279
COSMIC: CENPS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175279ENST00000309048Q8N2Z9
ENSG00000175279ENST00000462462A0A0U1RQL5
ENSG00000175279ENST00000477755K7ESB0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279
DNA RepairREACTOMER-HSA-73894
Fanconi Anemia PathwayREACTOMER-HSA-6783310

References

Pubmed IDYearTitleCitations
243905792014The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.16
245228852014A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle.13
246990632014The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability.10
243905792014The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.16
245228852014A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle.13
246990632014The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability.10
238867072013Structural peculiarities of the (MHF1-MHF2)4 octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: a solution SAXS study.2
242562822013Emerging roles for centromere-associated proteins in DNA repair and genetic recombination.9
238867072013Structural peculiarities of the (MHF1-MHF2)4 octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: a solution SAXS study.2
242562822013Emerging roles for centromere-associated proteins in DNA repair and genetic recombination.9
225106872012The structure of the FANCM-MHF complex reveals physical features for functional assembly.35
225106872012The structure of the FANCM-MHF complex reveals physical features for functional assembly.35
203474292010MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.119
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
203474292010MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.119

Citation

Dessen P

CENPS (centromere protein S)

Atlas Genet Cytogenet Oncol Haematol. 2016-09-01

Online version: http://atlasgeneticsoncology.org/gene/55946/favicon/css/js/_common.js