GRM2 (glutamate metabotropic receptor 2)

2016-10-01  

Identity

HGNC
GRM2
LOCATION
3p21.2
LOCUSID
2912
ALIAS
GLUR2,GPRC1B,MGLUR2,mGlu2

Other Information

Locus ID:

NCBI: 2912
MIM: 604099
HGNC: 4594
Ensembl: ENSG00000164082

Variants:

dbSNP: 2912
ClinVar: 2912
TCGA: ENSG00000164082
COSMIC: GRM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164082ENST00000296479H7BXL3
ENSG00000164082ENST00000395052Q14416
ENSG00000164082ENST00000419928C9JD41
ENSG00000164082ENST00000442933C9JL63

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387398002024Exploring the activation mechanism of metabotropic glutamate receptor 2.0
387398002024Exploring the activation mechanism of metabotropic glutamate receptor 2.0
368894322023The crosstalk between 5-HT(2A)R and mGluR2 in schizophrenia.7
376291222023Heterodimerization of Chemoreceptors TAS1R3 and mGlu(2) in Human Blood Leukocytes.0
368894322023The crosstalk between 5-HT(2A)R and mGluR2 in schizophrenia.7
376291222023Heterodimerization of Chemoreceptors TAS1R3 and mGlu(2) in Human Blood Leukocytes.0
333981672021Conformational rearrangement during activation of a metabotropic glutamate receptor.30
341355092021Structures of human mGlu2 and mGlu7 homo- and heterodimers.47
341355102021Structures of G(i)-bound metabotropic glutamate receptors mGlu2 and mGlu4.52
341940392021G-protein activation by a metabotropic glutamate receptor.55
343879612021DNA methylation changes in genes involved in inflammation and depression in fibromyalgia: a pilot study.4
345218242021Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state.20
333981672021Conformational rearrangement during activation of a metabotropic glutamate receptor.30
341355092021Structures of human mGlu2 and mGlu7 homo- and heterodimers.47
341355102021Structures of G(i)-bound metabotropic glutamate receptors mGlu2 and mGlu4.52

Citation

Dessen P

GRM2 (glutamate metabotropic receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55952