POLR3G (RNA polymerase III subunit G)

2016-10-01 Affiliation

Identity

HGNC

POLR3G

LOCATION

5q14.3

LOCUSID

10622

ALIAS

C31,RPC32,RPC7

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10622
MIM: 617456
HGNC: 30075
Ensembl: ENSG00000113356

Variants:

dbSNP: 10622
ClinVar: 10622
TCGA: ENSG00000113356
COSMIC: POLR3G

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000113356	ENST00000399107	O15318
ENSG00000113356	ENST00000399107	A0A024RAM1
ENSG00000113356	ENST00000503373	D6R9U7
ENSG00000113356	ENST00000503973	D6R921
ENSG00000113356	ENST00000504930	O15318
ENSG00000113356	ENST00000504930	A0A024RAM1
ENSG00000113356	ENST00000505345	D6RIT0
ENSG00000113356	ENST00000512239	D6REQ0
ENSG00000113356	ENST00000514483	D6RJH6
ENSG00000113356	ENST00000651687	O15318
ENSG00000113356	ENST00000651687	A0A024RAM1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Pyrimidine metabolism	KEGG	ko00240
RNA polymerase	KEGG	ko03020
Purine metabolism	KEGG	hsa00230
Pyrimidine metabolism	KEGG	hsa00240
RNA polymerase	KEGG	hsa03020
Cytosolic DNA-sensing pathway	KEGG	ko04623
Cytosolic DNA-sensing pathway	KEGG	hsa04623
Metabolic pathways	KEGG	hsa01100
RNA polymerase III, eukaryotes	KEGG	hsa_M00181
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
RNA polymerase III, eukaryotes	KEGG	M00181
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Cytosolic sensors of pathogen-associated DNA	REACTOME	R-HSA-1834949
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	REACTOME	R-HSA-504046
RNA Polymerase III Transcription	REACTOME	R-HSA-74158
RNA Polymerase III Abortive And Retractive Initiation	REACTOME	R-HSA-749476
RNA Polymerase III Transcription Initiation	REACTOME	R-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 Promoter	REACTOME	R-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 Promoter	REACTOME	R-HSA-76066
RNA Polymerase III Transcription Initiation From Type 3 Promoter	REACTOME	R-HSA-76071
RNA Polymerase III Chain Elongation	REACTOME	R-HSA-73780
RNA Polymerase III Transcription Termination	REACTOME	R-HSA-73980

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA447230	HIV	Disease	ClinicalAnnotation	associated		PD	21810746
PA450616	nevirapine	Chemical	ClinicalAnnotation	associated		PD	21810746

References

Pubmed ID	Year	Title	Citations
37933949	2023	POLR3G promotes EMT via PI3K/AKT signaling pathway in bladder cancer.	1
37933949	2023	POLR3G promotes EMT via PI3K/AKT signaling pathway in bladder cancer.	1
35637192	2022	A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA.	12
35637192	2022	A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA.	12
33626331	2021	RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination.	56
33626331	2021	RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination.	56
30820548	2019	Effects on prostate cancer cells of targeting RNA polymerase III.	22
30972912	2019	Genetic variation in FCER1A predicts peginterferon alfa-2a-induced hepatitis B surface antigen clearance in East Asian patients with chronic hepatitis B.	2
30820548	2019	Effects on prostate cancer cells of targeting RNA polymerase III.	22
30972912	2019	Genetic variation in FCER1A predicts peginterferon alfa-2a-induced hepatitis B surface antigen clearance in East Asian patients with chronic hepatitis B.	2
28494942	2017	RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA(+) and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells.	14
28494942	2017	RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA(+) and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells.	14
21898682	2011	A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells.	31
21898682	2011	A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells.	31

Citation

Dessen P

POLR3G (RNA polymerase III subunit G)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55969