CLASP1 (cytoplasmic linker associated protein 1)

2016-10-01  

Identity

HGNC
CLASP1
LOCATION
2q14.2
LOCUSID
23332
ALIAS
MAST1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23332
MIM: 605852
HGNC: 17088
Ensembl: ENSG00000074054

Variants:

dbSNP: 23332
ClinVar: 23332
TCGA: ENSG00000074054
COSMIC: CLASP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074054ENST00000263710Q7Z460
ENSG00000074054ENST00000397587Q7Z460
ENSG00000074054ENST00000409078Q7Z460
ENSG00000074054ENST00000418989C9J151
ENSG00000074054ENST00000449975C9JP76
ENSG00000074054ENST00000452274H0Y5T1
ENSG00000074054ENST00000455322F8WA11
ENSG00000074054ENST00000541377Q7Z460
ENSG00000074054ENST00000646274Q7Z460

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Role of Abl in Robo-Slit signalingREACTOMER-HSA-428890
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
340838102021Differential regulation of single microtubules and bundles by a three-protein module.6
340838102021Differential regulation of single microtubules and bundles by a three-protein module.6
273781692016Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.23
279396862016Mesenchymal Cell Invasion Requires Cooperative Regulation of Persistent Microtubule Growth by SLAIN2 and CLASP1.35
273781692016Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.23
279396862016Mesenchymal Cell Invasion Requires Cooperative Regulation of Persistent Microtubule Growth by SLAIN2 and CLASP1.35
248590052014CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover.125
248590052014CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover.125
231070732013Host microtubule plus-end binding protein CLASP1 influences sequential steps in the Trypanosoma cruzi infection process.6
237272312013A cryptic TOG domain with a distinct architecture underlies CLASP-dependent bipolar spindle formation.32
237830282013RanGTP and CLASP1 cooperate to position the mitotic spindle.17
239401182013Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex.25
231070732013Host microtubule plus-end binding protein CLASP1 influences sequential steps in the Trypanosoma cruzi infection process.6
237272312013A cryptic TOG domain with a distinct architecture underlies CLASP-dependent bipolar spindle formation.32
237830282013RanGTP and CLASP1 cooperate to position the mitotic spindle.17

Citation

Dessen P

CLASP1 (cytoplasmic linker associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55998/gene-fusions-explorer/js/cancer-prone-explorer/