CD84 (CD84 molecule)

2016-10-01 Affiliation

Identity

HGNC

CD84

LOCATION

1q23.3

LOCUSID

8832

ALIAS

LY9B,SLAMF5,hCD84,mCD84

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8832
MIM: 604513
HGNC: 1704
Ensembl: ENSG00000066294

Variants:

dbSNP: 8832
ClinVar: 8832
TCGA: ENSG00000066294
COSMIC: CD84

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000066294	ENST00000311224	Q9UIB8
ENSG00000066294	ENST00000368048	Q9UIB8
ENSG00000066294	ENST00000368051	Q9UIB8
ENSG00000066294	ENST00000368054	Q9UIB8
ENSG00000066294	ENST00000534968	Q9UIB8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA443434	Arthritis, Rheumatoid	Disease	ClinicalAnnotation	associated	PD	27564082
PA445451	Psoriasis	Disease	ClinicalAnnotation	associated	PD	27564082
PA449515	etanercept	Chemical	ClinicalAnnotation	associated	PD	27564082

References

Pubmed ID	Year	Title	Citations
33465053	2021	CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma.	23
33465053	2021	CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma.	23
31772329	2020	Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner.	2
31772329	2020	Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner.	2
30514120	2019	The temporal pattern of immune and inflammatory proteins prior to a recurrent coronary event in post-acute coronary syndrome patients.	5
30514120	2019	The temporal pattern of immune and inflammatory proteins prior to a recurrent coronary event in post-acute coronary syndrome patients.	5
29434592	2018	Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8.	7
29434592	2018	Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8.	7
27452524	2017	CD84 mediates CLL-microenvironment interactions.	13
27452524	2017	CD84 mediates CLL-microenvironment interactions.	13
23435417	2014	CD84 is a survival receptor for CLL cells.	16
24635044	2014	CD84 is markedly up-regulated in Kawasaki disease arteriopathy.	4
23435417	2014	CD84 is a survival receptor for CLL cells.	16
24635044	2014	CD84 is markedly up-regulated in Kawasaki disease arteriopathy.	4
23555300	2013	Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.	78

Citation

Dessen P

CD84 (CD84 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56016