PELO (pelota mRNA surveillance and ribosome rescue factor)

2016-10-01  

Identity

HGNC
PELO
LOCATION
5q11.2
LOCUSID
53918
ALIAS
CGI-17,PRO1770

Other Information

Locus ID:

NCBI: 53918
MIM: 605757
HGNC: 8829
Ensembl: ENSG00000152684

Variants:

dbSNP: 53918
ClinVar: 53918
TCGA: ENSG00000152684
COSMIC: PELO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152684ENST00000274311Q9BRX2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369481922023Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity.6
369481922023Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity.6
282133792017Slowed decay of mRNAs enhances platelet specific translation.36
282133792017Slowed decay of mRNAs enhances platelet specific translation.36
275438242016Conserved functions of human Pelota in mRNA quality control of nonstop mRNA.10
276814152016Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets.75
275438242016Conserved functions of human Pelota in mRNA quality control of nonstop mRNA.10
276814152016Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets.75
234354262014PELO negatively regulates HER receptor signalling and metastasis.8
234354262014PELO negatively regulates HER receptor signalling and metastasis.8
236672532013The Hbs1-Dom34 protein complex functions in non-stop mRNA decay in mammalian cells.43
236672532013The Hbs1-Dom34 protein complex functions in non-stop mRNA decay in mammalian cells.43
214481322011Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.172
214481322011Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.172
203062912010A three-stage genome-wide association study of general cognitive ability: hunting the small effects.40

Citation

Dessen P

PELO (pelota mRNA surveillance and ribosome rescue factor)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56038