CRLF1 (cytokine receptor like factor 1)

2016-10-01  

Identity

HGNC
CRLF1
LOCATION
19p13.11
LOCUSID
9244
ALIAS
CISS,CISS1,CLF,CLF-1,NR6,zcytor5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9244
MIM: 604237
HGNC: 2364
Ensembl: ENSG00000006016

Variants:

dbSNP: 9244
ClinVar: 9244
TCGA: ENSG00000006016
COSMIC: CRLF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006016ENST00000392386O75462
ENSG00000006016ENST00000597131M0QZL6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382625642024Identification and validation of CRLF1 and NRG1 as immune-related signatures in hypertrophic scar.0
382625642024Identification and validation of CRLF1 and NRG1 as immune-related signatures in hypertrophic scar.0
379102542023Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1.1
379102542023Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1.1
350551762022CRLF1 and CLCF1 in Development, Health and Disease.10
356995172022Clinical and molecular genetic findings of Crisponi/cold-induced sweating syndrome (CS/CISS) spectrum in patients from Turkey.0
359845562022Novel Mutations in CRLF1: Case Reports with Crisponi Syndrome.0
350551762022CRLF1 and CLCF1 in Development, Health and Disease.10
356995172022Clinical and molecular genetic findings of Crisponi/cold-induced sweating syndrome (CS/CISS) spectrum in patients from Turkey.0
359845562022Novel Mutations in CRLF1: Case Reports with Crisponi Syndrome.0
339100952021Three new cases of Crisponi /cold induced sweating syndrome (CS/CISS1) in Turkish families.0
339100952021Three new cases of Crisponi /cold induced sweating syndrome (CS/CISS1) in Turkish families.0
314978772020Crisponi/cold-induced sweating syndrome: Differential diagnosis, pathogenesis and treatment concepts.4
329829612020CRLF1-MYH9 Interaction Regulates Proliferation and Metastasis of Papillary Thyroid Carcinoma Through the ERK/ETV4 Axis.7
314978772020Crisponi/cold-induced sweating syndrome: Differential diagnosis, pathogenesis and treatment concepts.4

Citation

Dessen P

CRLF1 (cytokine receptor like factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56054