EPX (eosinophil peroxidase)

2016-10-01  

Identity

HGNC
EPX
LOCATION
17q22
LOCUSID
8288
ALIAS
EPO,EPP,EPX-PEN,EPXD

Other Information

Locus ID:

NCBI: 8288
MIM: 131399
HGNC: 3423
Ensembl: ENSG00000121053

Variants:

dbSNP: 8288
ClinVar: 8288
TCGA: ENSG00000121053
COSMIC: EPX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121053ENST00000225371P11678

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
AsthmaKEGGko05310
AsthmaKEGGhsa05310
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372550542024Eosinophil Peroxidase: A Biomarker for Eosinophilic Chronic Rhinosinusitis Agnostic of Polyp Status.0
383167912024Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase.0
372550542024Eosinophil Peroxidase: A Biomarker for Eosinophilic Chronic Rhinosinusitis Agnostic of Polyp Status.0
383167912024Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase.0
307388392019Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis.6
307388392019Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis.6
278367742017Peroxidase enzymes inhibit osteoclast differentiation and bone resorption.13
282600492017Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment.29
278367742017Peroxidase enzymes inhibit osteoclast differentiation and bone resorption.13
282600492017Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment.29
266454232016Nasal and pharyngeal eosinophil peroxidase levels in adults with poorly controlled asthma correlate with sputum eosinophilia.13
275199532016Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling.5
275873972016Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma.17
266454232016Nasal and pharyngeal eosinophil peroxidase levels in adults with poorly controlled asthma correlate with sputum eosinophilia.13
275199532016Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling.5

Citation

Dessen P

EPX (eosinophil peroxidase)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56108