PGA5 (pepsinogen A5)

2016-10-01  

Identity

HGNC
PGA5
LOCATION
11q12.2
LOCUSID
5222
ALIAS
Pg5

Other Information

Locus ID:

NCBI: 5222
MIM: 169730
HGNC: 8887
Ensembl: ENSG00000256713

Variants:

dbSNP: 5222
ClinVar: 5222
TCGA: ENSG00000256713
COSMIC: PGA5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000256713ENST00000312403P0DJD9
ENSG00000256713ENST00000451616C9JM59
ENSG00000256713ENST00000541528F5GWT0

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Metabolism of proteinsREACTOMER-HSA-392499
Surfactant metabolismREACTOMER-HSA-5683826

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
332200272020The Role of Salivary Pepsin in the Diagnosis of Gastroesophageal Reflux Disease (GERD) Evaluated Using High-Resolution Manometry and 24-Hour Multichannel Intraluminal Impedance-pH Monitoring.5
332200272020The Role of Salivary Pepsin in the Diagnosis of Gastroesophageal Reflux Disease (GERD) Evaluated Using High-Resolution Manometry and 24-Hour Multichannel Intraluminal Impedance-pH Monitoring.5
310461392019Esophageal pepsin and proton pump synthesis in barrett's esophagus and esophageal adenocarcinoma.8
310461392019Esophageal pepsin and proton pump synthesis in barrett's esophagus and esophageal adenocarcinoma.8
242849442014Role of pepsin and pepsinogen: linking laryngopharyngeal reflux with otitis media with effusion in children.11
242849442014Role of pepsin and pepsinogen: linking laryngopharyngeal reflux with otitis media with effusion in children.11
233117202013Detection of pepsin in mouth swab: correlation with clinical gastroesophageal reflux in preterm infants.7
233117202013Detection of pepsin in mouth swab: correlation with clinical gastroesophageal reflux in preterm infants.7

Citation

Dessen P

PGA5 (pepsinogen A5)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56147