MKRN2 (makorin ring finger protein 2)

2016-10-01 Affiliation

Identity

HGNC

MKRN2

LOCATION

3p25.2

LOCUSID

23609

ALIAS

HSPC070,RNF62

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23609
MIM: 608426
HGNC: 7113
Ensembl: ENSG00000075975

Variants:

dbSNP: 23609
ClinVar: 23609
TCGA: ENSG00000075975
COSMIC: MKRN2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000075975	ENST00000170447	Q9H000
ENSG00000075975	ENST00000411987	Q9H000
ENSG00000075975	ENST00000448482	C9J494

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38753876	2024	Identifying cellular RNA-binding proteins during infection uncovers a role for MKRN2 in influenza mRNA trafficking.	1
38753876	2024	Identifying cellular RNA-binding proteins during infection uncovers a role for MKRN2 in influenza mRNA trafficking.	1
36938725	2023	MKRN1/2 serve as tumor suppressors in renal clear cell carcinoma by regulating the expression of p53.	1
37528788	2023	[Overexpression of MKRN2 Inhibits the Growth of Ovarian Cancer Cells].	0
36938725	2023	MKRN1/2 serve as tumor suppressors in renal clear cell carcinoma by regulating the expression of p53.	1
37528788	2023	[Overexpression of MKRN2 Inhibits the Growth of Ovarian Cancer Cells].	0
31814304	2020	Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease.	38
32560817	2020	Ubiquitination of IGF2BP3 by E3 ligase MKRN2 regulates the proliferation and migration of human neuroblastoma SHSY5Y cells.	12
31814304	2020	Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease.	38
32560817	2020	Ubiquitination of IGF2BP3 by E3 ligase MKRN2 regulates the proliferation and migration of human neuroblastoma SHSY5Y cells.	12
30103781	2018	MKRN2 inhibits migration and invasion of non-small-cell lung cancer by negatively regulating the PI3K/Akt pathway.	27
30103781	2018	MKRN2 inhibits migration and invasion of non-small-cell lung cancer by negatively regulating the PI3K/Akt pathway.	27
28378844	2017	MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses.	31
28378844	2017	MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses.	31
24675897	2014	Ubiquitous expression of MAKORIN-2 in normal and malignant hematopoietic cells and its growth promoting activity.	10

Citation

Dessen P

MKRN2 (makorin ring finger protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56213