DNPH1 (2-deoxynucleoside 5-phosphate N-hydrolase 1)

2016-10-01  

Identity

HGNC
DNPH1
LOCATION
6p21.1
LOCUSID
10591
ALIAS
C6orf108,RCL,dJ330M21.3

Other Information

Locus ID:

NCBI: 10591
MIM: 618762
HGNC: 21218
Ensembl: ENSG00000112667

Variants:

dbSNP: 10591
ClinVar: 10591
TCGA: ENSG00000112667
COSMIC: DNPH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112667ENST00000230431O43598
ENSG00000112667ENST00000393987O43598
ENSG00000112667ENST00000509253H0Y8X4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383500032024Human 2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1: The Catalytic Roles of Tyr24 and Asp80.0
383500032024Human 2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1: The Catalytic Roles of Tyr24 and Asp80.0
338331182021Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.43
338331182021Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.43
209623482010Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108.5
209623482010Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108.5
187268922008Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors.28
187268922008Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors.28

Citation

Dessen P

DNPH1 (2-deoxynucleoside 5-phosphate N-hydrolase 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56226/tumors-explorer/teaching-explorer/favicon/favicon-32x32.png