KCNK3 (potassium two pore domain channel subfamily K member 3)

2016-10-01  

Identity

HGNC
KCNK3
LOCATION
2p23.3
LOCUSID
3777
ALIAS
K2p3.1,OAT1,PPH4,TASK,TASK-1,TASK1,TBAK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3777
MIM: 603220
HGNC: 6278
Ensembl: ENSG00000171303

Variants:

dbSNP: 3777
ClinVar: 3777
TCGA: ENSG00000171303
COSMIC: KCNK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171303ENST00000302909O14649
ENSG00000171303ENST00000620977B9EIJ4

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Tandem pore domain potassium channelsREACTOMER-HSA-1296346
TWIK-releated acid-sensitive K+ channel (TASK)REACTOMER-HSA-1299316
Muscle contractionREACTOMER-HSA-397014
Aldosterone synthesis and secretionKEGGhsa04925
Aldosterone synthesis and secretionKEGGko04925
Cardiac conductionREACTOMER-HSA-5576891
Phase 4 - resting membrane potentialREACTOMER-HSA-5576886

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD31327267
PA448765candesartanChemicalClinicalAnnotationassociatedPD31327267

References

Pubmed IDYearTitleCitations
377935942023Activation of neurokinin-III receptors modulates human atrial TASK-1 currents.0
377935942023Activation of neurokinin-III receptors modulates human atrial TASK-1 currents.0
353018632022MicroRNAs Regulate TASK-1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation.10
360165022022Crosstalk between BMP signaling and KCNK3 in phenotypic switching of pulmonary vascular smooth muscle cells.3
361957572022Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea.6
353018632022MicroRNAs Regulate TASK-1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation.10
360165022022Crosstalk between BMP signaling and KCNK3 in phenotypic switching of pulmonary vascular smooth muscle cells.3
361957572022Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea.6
340382432021Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.4
340650882021KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.9
345713712021TASK-1 regulates mitochondrial function under hypoxia.1
350115892021Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors.3
340382432021Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.4
340650882021KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.9
345713712021TASK-1 regulates mitochondrial function under hypoxia.1

Citation

Dessen P

KCNK3 (potassium two pore domain channel subfamily K member 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56262/gene-fusions/gene-explorer/