STX8 (syntaxin 8)

2016-10-01  

Identity

HGNC
STX8
LOCATION
17p13.1
LOCUSID
9482
ALIAS
CARB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9482
MIM: 604203
HGNC: 11443
Ensembl: ENSG00000170310

Variants:

dbSNP: 9482
ClinVar: 9482
TCGA: ENSG00000170310
COSMIC: STX8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170310ENST00000306357Q9UNK0
ENSG00000170310ENST00000573016I3L305
ENSG00000170310ENST00000574431K7EQB1
ENSG00000170310ENST00000575294K7ER37
ENSG00000170310ENST00000575858I3L3D0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
343194032021Smuggle tau through a secret(ory) pathway.1
343194032021Smuggle tau through a secret(ory) pathway.1
304858522018Syntaxin 8 and the Endoplasmic Reticulum Processing of ΔF508-CFTR.4
304858522018Syntaxin 8 and the Endoplasmic Reticulum Processing of ΔF508-CFTR.4
270941272016Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes.16
270941272016Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes.16
254047412015Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability.15
255231462015Expression of syntaxin 8 in visceral adipose tissue is increased in obese patients with type 2 diabetes and related to markers of insulin resistance and inflammation.8
254047412015Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability.15
255231462015Expression of syntaxin 8 in visceral adipose tissue is increased in obese patients with type 2 diabetes and related to markers of insulin resistance and inflammation.8
246597812014Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.12
247435962014Cooperative endocytosis of the endosomal SNARE protein syntaxin-8 and the potassium channel TASK-1.11
246597812014Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.12
247435962014Cooperative endocytosis of the endosomal SNARE protein syntaxin-8 and the potassium channel TASK-1.11
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

STX8 (syntaxin 8)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56267/gene-fusions-explorer/favicon/css/card-gene.css