TRIM17 (tripartite motif containing 17)

2016-10-01  

Identity

HGNC
TRIM17
LOCATION
1q42.13
LOCUSID
51127
ALIAS
RBCC,RNF16,terf

Other Information

Locus ID:

NCBI: 51127
MIM: 606123
HGNC: 13430
Ensembl: ENSG00000162931

Variants:

dbSNP: 51127
ClinVar: 51127
TCGA: ENSG00000162931
COSMIC: TRIM17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162931ENST00000295033Q9Y577
ENSG00000162931ENST00000295033A0A024R3T1
ENSG00000162931ENST00000355586J3KNZ3
ENSG00000162931ENST00000366697Q9Y577
ENSG00000162931ENST00000366697A0A024R3T1
ENSG00000162931ENST00000366698Q9Y577
ENSG00000162931ENST00000366698A0A024R3T1
ENSG00000162931ENST00000456946Q9Y577
ENSG00000162931ENST00000457345J3KQG0
ENSG00000162931ENST00000479800E5RJW6
ENSG00000162931ENST00000520264E5RI62

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372197682023TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer.5
372197682023TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer.5
358945532022MiR-1246 is responsible for lung cancer cells-derived exosomes-mediated promoting effects on lung cancer stemness via targeting TRIM17.5
358945532022MiR-1246 is responsible for lung cancer cells-derived exosomes-mediated promoting effects on lung cancer stemness via targeting TRIM17.5
300424932019TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1.33
314098982019LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression.25
300424932019TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1.33
314098982019LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression.25
304858142018The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.21
304858142018The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.21
275620682016TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation.23
275620682016TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation.23
252159462015Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17.17
252159462015Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17.17
220238002012Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.31

Citation

Dessen P

TRIM17 (tripartite motif containing 17)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56316