PROKR2 (prokineticin receptor 2)

2016-10-01  

Identity

HGNC
PROKR2
LOCATION
20p12.3
LOCUSID
128674
ALIAS
GPR73L1,GPR73b,GPRg2,HH3,KAL3,PKR2,dJ680N4.3

Other Information

Locus ID:

NCBI: 128674
MIM: 607123
HGNC: 15836
Ensembl: ENSG00000101292

Variants:

dbSNP: 128674
ClinVar: 128674
TCGA: ENSG00000101292
COSMIC: PROKR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101292ENST00000217270Q8NFJ6

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
382725122024Additional mutation in PROKR2 and phenotypic differences in a Kallmann syndrome/normosmic congenital hypogonadotropic hypogonadism family carrying FGFR1 missense mutation.0
382725122024Additional mutation in PROKR2 and phenotypic differences in a Kallmann syndrome/normosmic congenital hypogonadotropic hypogonadism family carrying FGFR1 missense mutation.0
366949822023A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism.1
371888882023Prokineticin 2 as a potential biomarker for the diagnosis of Kawasaki disease.1
373382952023PROKR2 Mutations in Patients with Short Stature Who Have Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency.1
366949822023A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism.1
371888882023Prokineticin 2 as a potential biomarker for the diagnosis of Kawasaki disease.1
373382952023PROKR2 Mutations in Patients with Short Stature Who Have Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency.1
351730482022Trafficking-defective mutant PROKR2 cycles between endoplasmic reticulum and Golgi to attenuate endoplasmic reticulum stress.1
352367882022Biallelic PROKR2 variants and congenital hypogonadotropic hypogonadism: a case report and a literature review.2
359222192022[Analysis of PROKR2 gene mutation in patients with hypogonadotropic hypogonadism].0
351730482022Trafficking-defective mutant PROKR2 cycles between endoplasmic reticulum and Golgi to attenuate endoplasmic reticulum stress.1
352367882022Biallelic PROKR2 variants and congenital hypogonadotropic hypogonadism: a case report and a literature review.2
359222192022[Analysis of PROKR2 gene mutation in patients with hypogonadotropic hypogonadism].0
334120902021Analysis of role of aromatic residues in extracellular loop 2 of Prokineticin receptor 2 in ligand binding probed with genetically encoded photo-crosslinkers.3

Citation

Dessen P

PROKR2 (prokineticin receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56318