HOOK1 (hook microtubule tethering protein 1)

2016-10-01 Affiliation

Identity

HGNC

HOOK1

LOCATION

1p32.1

LOCUSID

51361

ALIAS

HK1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51361
MIM: 607820
HGNC: 19884
Ensembl: ENSG00000134709

Variants:

dbSNP: 51361
ClinVar: 51361
TCGA: ENSG00000134709
COSMIC: HOOK1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000134709	ENST00000371208	Q9UJC3
ENSG00000134709	ENST00000455990	B1AK95

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37085921	2023	HOOK1 Inhibits the Progression of Renal Cell Carcinoma via TGF-β and TNFSF13B/VEGF-A Axis.	4
37085921	2023	HOOK1 Inhibits the Progression of Renal Cell Carcinoma via TGF-β and TNFSF13B/VEGF-A Axis.	4
29330334	2018	Detection of heterozygous mutation in hook microtubule-tethering protein 1 in three patients with decapitated and decaudated spermatozoa syndrome.	18
29953894	2018	Clinicopathological and prognostic significance of SHP2 and Hook1 expression in patients with thyroid carcinoma.	11
29330334	2018	Detection of heterozygous mutation in hook microtubule-tethering protein 1 in three patients with decapitated and decaudated spermatozoa syndrome.	18
29953894	2018	Clinicopathological and prognostic significance of SHP2 and Hook1 expression in patients with thyroid carcinoma.	11
28718370	2017	Hook1 inhibits malignancy and epithelial-mesenchymal transition in hepatocellular carcinoma.	8
28718370	2017	Hook1 inhibits malignancy and epithelial-mesenchymal transition in hepatocellular carcinoma.	8
27365401	2016	Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction.	62
27365401	2016	Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction.	62
25331952	2014	SHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.	22
25331952	2014	SHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.	22
23589492	2013	Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1.	79
23589492	2013	Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1.	79
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78

Citation

Dessen P

HOOK1 (hook microtubule tethering protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56325/haematological-explorer/img/css/template-nav.css