IFNA5 (interferon alpha 5)

2016-10-01 Affiliation

Identity

HGNC

IFNA5

LOCATION

9p21.3

LOCUSID

3442

ALIAS

IFN-alpha-5,IFN-alphaG,INA5,INFA5,leIF

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3442
MIM: 147565
HGNC: 5426
Ensembl: ENSG00000147873

Variants:

dbSNP: 3442
ClinVar: 3442
TCGA: ENSG00000147873
COSMIC: IFNA5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000147873	ENST00000610521	P01569

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Toll-like receptor signaling pathway	KEGG	ko04620
Jak-STAT signaling pathway	KEGG	ko04630
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Autoimmune thyroid disease	KEGG	ko05320
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Toll-like receptor signaling pathway	KEGG	hsa04620
Jak-STAT signaling pathway	KEGG	hsa04630
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Autoimmune thyroid disease	KEGG	hsa05320
RIG-I-like receptor signaling pathway	KEGG	ko04622
RIG-I-like receptor signaling pathway	KEGG	hsa04622
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Cytosolic DNA-sensing pathway	KEGG	ko04623
Cytosolic DNA-sensing pathway	KEGG	hsa04623
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Hepatitis B	KEGG	hsa05161
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
TRAF6 mediated IRF7 activation	REACTOME	R-HSA-933541
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon alpha/beta signaling	REACTOME	R-HSA-909733
Regulation of IFNA signaling	REACTOME	R-HSA-912694
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	37
20331378	2010	Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.	30
20503287	2010	Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.	30
20574843	2010	Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.	21
20588308	2010	Dengue hemorrhagic fever is associated with polymorphisms in JAK1.	12
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	37
20331378	2010	Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.	30
20503287	2010	Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.	30
20574843	2010	Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.	21
20588308	2010	Dengue hemorrhagic fever is associated with polymorphisms in JAK1.	12
19258923	2009	Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.	31
19258923	2009	Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.	31
18953482	2008	Polymorphisms of interferons and their receptors in the genetics of severe RSV-associated diseases.	2
19000144	2008	Genetic association of interferon-alpha subtypes 1, 2 and 5 in systemic lupus erythematosus.	6
19000144	2008	Genetic association of interferon-alpha subtypes 1, 2 and 5 in systemic lupus erythematosus.	6

Citation

Dessen P

IFNA5 (interferon alpha 5)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56374