ZP3 (zona pellucida glycoprotein 3)

2016-10-01  

Identity

HGNC
ZP3
LOCATION
7q11.23
LOCUSID
7784
ALIAS
OOMD3,ZP3A,ZP3B,ZPC,Zp-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7784
MIM: 182889
HGNC: 13189
Ensembl: ENSG00000188372

Variants:

dbSNP: 7784
ClinVar: 7784
TCGA: ENSG00000188372
COSMIC: ZP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188372ENST00000336517P21754
ENSG00000188372ENST00000394857P21754
ENSG00000188372ENST00000394860H0Y3M4
ENSG00000188372ENST00000416245E9PFI9

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ReproductionREACTOMER-HSA-1474165
FertilizationREACTOMER-HSA-1187000
Interaction With The Zona PellucidaREACTOMER-HSA-1300644

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369319172023Novel variants in ZP1, ZP2 and ZP3 associated with empty follicle syndrome and abnormal zona pellucida.4
369319172023Novel variants in ZP1, ZP2 and ZP3 associated with empty follicle syndrome and abnormal zona pellucida.4
347369662022Novel expression of zona pellucida 3 protein in normal testis; potential functional implications.4
348165292022A novel gene mutation in ZP3 loop region identified in patients with empty follicle syndrome.4
353667442022Novel mutations in ZP2 and ZP3 cause female infertility in three patients.2
363357662022Novel mutations in TUBB8 and ZP3 cause human oocyte maturation arrest and female infertility.2
347369662022Novel expression of zona pellucida 3 protein in normal testis; potential functional implications.4
348165292022A novel gene mutation in ZP3 loop region identified in patients with empty follicle syndrome.4
353667442022Novel mutations in ZP2 and ZP3 cause female infertility in three patients.2
363357662022Novel mutations in TUBB8 and ZP3 cause human oocyte maturation arrest and female infertility.2
331401782021A novel mutation in ZP3 causes empty follicle syndrome and abnormal zona pellucida formation.14
336048052021A novel homozygous variant in ZP2 causes abnormal zona pellucida formation and female infertility.7
331401782021A novel mutation in ZP3 causes empty follicle syndrome and abnormal zona pellucida formation.14
336048052021A novel homozygous variant in ZP2 causes abnormal zona pellucida formation and female infertility.7
325695272020Zona Pellucida Proteins, Fibrils, and Matrix.24

Citation

Dessen P

ZP3 (zona pellucida glycoprotein 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56382