ERVFRD-1 (endogenous retrovirus group FRD member 1, envelope)

2016-10-01  

Identity

HGNC
ERVFRD-1
LOCATION
6p24.2
LOCUSID
405754
ALIAS
ERVFRDE1,GLLL6191,HERV-FRD,HERV-W/FRD,UNQ6191,envFRD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 405754
MIM: 610524
HGNC: 33823
Ensembl: ENSG00000244476

Variants:

dbSNP: 405754
ClinVar: 405754
TCGA: ENSG00000244476
COSMIC: ERVFRD-1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000244476ENST00000472091P60508
ENSG00000244476ENST00000542862P60508

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
367685812023Interaction between Long Noncoding RNAs and Syncytin-1/Syncytin-2 Genes and Transcripts: How Noncoding RNAs May Affect Pregnancy in Patients with Systemic Lupus Erythematosus.1
376958912023Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment.2
367685812023Interaction between Long Noncoding RNAs and Syncytin-1/Syncytin-2 Genes and Transcripts: How Noncoding RNAs May Affect Pregnancy in Patients with Systemic Lupus Erythematosus.1
376958912023Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment.2
357108382022Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2.15
357108382022Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2.15
339930532021HERV-W envelope expression in blood leukocytes as a marker of disease severity of COVID-19.8
339930532021HERV-W envelope expression in blood leukocytes as a marker of disease severity of COVID-19.8
313180212020Endogenous retrovirus-encoded Syncytin-2 contributes to exosome-mediated immunosuppression of T cells†.43
321453272020Expression of the syncytin-1 and syncytin-2 genes in the trophoblastic tissue of the early pregnancy losses with normal and abnormal karyotypes.4
313180212020Endogenous retrovirus-encoded Syncytin-2 contributes to exosome-mediated immunosuppression of T cells†.43
321453272020Expression of the syncytin-1 and syncytin-2 genes in the trophoblastic tissue of the early pregnancy losses with normal and abnormal karyotypes.4
297509652018A tag SNP in syncytin-2 3-UTR significantly correlates with the risk of severe preeclampsia.5
297509652018A tag SNP in syncytin-2 3-UTR significantly correlates with the risk of severe preeclampsia.5
268531552016Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2.6

Citation

Dessen P

ERVFRD-1 (endogenous retrovirus group FRD member 1, envelope)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56408