DBF4B (DBF4 zinc finger B)

2016-10-01  

Identity

HGNC
DBF4B
LOCATION
17q21.31
LOCUSID
80174
ALIAS
ASKL1,CHIFB,DRF1,ZDBF1B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80174
MIM: 611661
HGNC: 17883
Ensembl: ENSG00000161692

Variants:

dbSNP: 80174
ClinVar: 80174
TCGA: ENSG00000161692
COSMIC: DBF4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161692ENST00000315005Q8NFT6
ENSG00000161692ENST00000393547Q8NFT6
ENSG00000161692ENST00000526924B4E099

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
388650902024DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.0
388650902024DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.0
292623222017SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing.38
292623222017SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing.38
191116652008The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control.37
191116652008The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control.37
156682322005A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases.28
156682322005A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases.28
120654292002Drf1, a novel regulatory subunit for human Cdc7 kinase.33
120654292002Drf1, a novel regulatory subunit for human Cdc7 kinase.33

Citation

Dessen P

DBF4B (DBF4 zinc finger B)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56410/js/lib/gene-fusions-explorer/css/template-card.css