SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein)

2016-10-01  

Identity

HGNC
SYNCRIP
LOCATION
6q14.3
LOCUSID
10492
ALIAS
GRY-RBP,GRYRBP,HNRNPQ,HNRPQ1,NSAP1,PP68,hnRNP-Q
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10492
MIM: 616686
HGNC: 16918
Ensembl: ENSG00000135316

Variants:

dbSNP: 10492
ClinVar: 10492
TCGA: ENSG00000135316
COSMIC: SYNCRIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135316ENST00000355238O60506
ENSG00000135316ENST00000369622O60506
ENSG00000135316ENST00000444272F6UXX1
ENSG00000135316ENST00000616122B7Z645

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375593472023Oculopharyngeal muscular dystrophy mutations link the RNA-binding protein HNRNPQ to autophagosome biogenesis.1
375593472023Oculopharyngeal muscular dystrophy mutations link the RNA-binding protein HNRNPQ to autophagosome biogenesis.1
341577902021Further evidence for de novo variants in SYNCRIP as the cause of a neurodevelopmental disorder.6
341577902021Further evidence for de novo variants in SYNCRIP as the cause of a neurodevelopmental disorder.6
317915862020ATP binds nucleic-acid-binding domains beyond RRM fold.4
319072082020SYNCRIP, a new player in pri-let-7a processing.14
327706262020A novel antisense lncRNA NT5E promotes progression by modulating the expression of SYNCRIP and predicts a poor prognosis in pancreatic cancer.9
317915862020ATP binds nucleic-acid-binding domains beyond RRM fold.4
319072082020SYNCRIP, a new player in pri-let-7a processing.14
327706262020A novel antisense lncRNA NT5E promotes progression by modulating the expression of SYNCRIP and predicts a poor prognosis in pancreatic cancer.9
307552802019Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS.16
307552802019Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS.16
294835122018A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets.62
298848182018The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes.12
302668142018Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation.23

Citation

Dessen P

SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56491