SIGLEC6 (sialic acid binding Ig like lectin 6)

2016-10-01  

Identity

HGNC
SIGLEC6
LOCATION
19q13.41
LOCUSID
946
ALIAS
CD327,CD33L,CD33L1,CD33L2,CDW327,OBBP1

Other Information

Locus ID:

NCBI: 946
MIM: 604405
HGNC: 10875
Ensembl: ENSG00000105492

Variants:

dbSNP: 946
ClinVar: 946
TCGA: ENSG00000105492
COSMIC: SIGLEC6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105492ENST00000343300O43699
ENSG00000105492ENST00000346477O43699
ENSG00000105492ENST00000359982O43699
ENSG00000105492ENST00000391797O43699
ENSG00000105492ENST00000425629O43699
ENSG00000105492ENST00000425629A0A024R4K4
ENSG00000105492ENST00000436458O43699

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
359530012023Expression and regulation of Siglec-6 (CD327) on human mast cells and basophils.6
370874952023Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket.4
359530012023Expression and regulation of Siglec-6 (CD327) on human mast cells and basophils.6
370874952023Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket.4
341474042022Siglec-6 as a New Potential Immune Checkpoint for Bladder Cancer Patients.6
354067052022Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells.14
361136262022Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/β-catenin signaling in preeclampsia.3
363598232022Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment.4
341474042022Siglec-6 as a New Potential Immune Checkpoint for Bladder Cancer Patients.6
354067052022Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells.14
361136262022Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/β-catenin signaling in preeclampsia.3
363598232022Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment.4
329988192020Glycosylated Siglec-6 expression in syncytiotrophoblast-derived extracellular vesicles from preeclampsia placentas.6
329988192020Glycosylated Siglec-6 expression in syncytiotrophoblast-derived extracellular vesicles from preeclampsia placentas.6
302943272018Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells.30

Citation

Dessen P

SIGLEC6 (sialic acid binding Ig like lectin 6)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56555