SGSM2 (small G protein signaling modulator 2)

2016-10-01 Affiliation

Identity

HGNC

SGSM2

LOCATION

17p13.3

LOCUSID

9905

ALIAS

RUTBC1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9905
MIM: 611418
HGNC: 29026
Ensembl: ENSG00000141258

Variants:

dbSNP: 9905
ClinVar: 9905
TCGA: ENSG00000141258
COSMIC: SGSM2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000141258	ENST00000268989	O43147
ENSG00000141258	ENST00000426855	O43147
ENSG00000141258	ENST00000426855	B9A6J3
ENSG00000141258	ENST00000570431	I3L361
ENSG00000141258	ENST00000572875	I3L1Y7
ENSG00000141258	ENST00000572925	I3NI18
ENSG00000141258	ENST00000573062	V9GYJ0
ENSG00000141258	ENST00000573851	J3QSA2
ENSG00000141258	ENST00000574563	O43147
ENSG00000141258	ENST00000574650	V9GYD2

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35264562	2022	SGSM2 inhibits thyroid cancer progression by activating RAP1 and enhancing competitive RAS inhibition.	4
35264562	2022	SGSM2 inhibits thyroid cancer progression by activating RAP1 and enhancing competitive RAS inhibition.	4
30489189	2020	Weighted gene co-expression network analysis identifies specific modules and hub genes related to subsyndromal symptomatic depression.	8
30489189	2020	Weighted gene co-expression network analysis identifies specific modules and hub genes related to subsyndromal symptomatic depression.	8
30744493	2019	Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.	5
30744493	2019	Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.	5
26620560	2016	RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.	20
26620560	2016	RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.	20
21808068	2011	RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.	37
21808068	2011	RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.	37
17509819	2007	Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.	27
17509819	2007	Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.	27

Citation

Dessen P

SGSM2 (small G protein signaling modulator 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56587/img/cancer-prone-explorer/teaching-explorer/