SGSM2 (small G protein signaling modulator 2)

2016-10-01  

Identity

HGNC
LOCATION
17p13.3
LOCUSID
ALIAS
RUTBC1
FUSION GENES

Other Information

Locus ID:

NCBI: 9905
MIM: 611418
HGNC: 29026
Ensembl: ENSG00000141258

Variants:

dbSNP: 9905
ClinVar: 9905
TCGA: ENSG00000141258
COSMIC: SGSM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141258ENST00000268989O43147
ENSG00000141258ENST00000426855O43147
ENSG00000141258ENST00000426855B9A6J3
ENSG00000141258ENST00000570431I3L361
ENSG00000141258ENST00000572875I3L1Y7
ENSG00000141258ENST00000572925I3NI18
ENSG00000141258ENST00000573062V9GYJ0
ENSG00000141258ENST00000573851J3QSA2
ENSG00000141258ENST00000574563O43147
ENSG00000141258ENST00000574650V9GYD2

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
352645622022SGSM2 inhibits thyroid cancer progression by activating RAP1 and enhancing competitive RAS inhibition.4
352645622022SGSM2 inhibits thyroid cancer progression by activating RAP1 and enhancing competitive RAS inhibition.4
304891892020Weighted gene co-expression network analysis identifies specific modules and hub genes related to subsyndromal symptomatic depression.8
304891892020Weighted gene co-expression network analysis identifies specific modules and hub genes related to subsyndromal symptomatic depression.8
307444932019Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.5
307444932019Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.5
266205602016RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.20
266205602016RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.20
218080682011RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.37
218080682011RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.37
175098192007Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.27
175098192007Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.27

Citation

Dessen P

SGSM2 (small G protein signaling modulator 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56587/tumors-explorer/js/lib/teaching-explorer/