P2RX3 (purinergic receptor P2X 3)

2016-10-01  

Identity

HGNC
P2RX3
LOCATION
11q12.1
LOCUSID
5024
ALIAS
P2X3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5024
MIM: 600843
HGNC: 8534
Ensembl: ENSG00000109991

Variants:

dbSNP: 5024
ClinVar: 5024
TCGA: ENSG00000109991
COSMIC: P2RX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109991ENST00000263314P56373
ENSG00000109991ENST00000534820H0YDR6
ENSG00000109991ENST00000616487A0A087X210

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Taste transductionKEGGko04742
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Taste transductionKEGGhsa04742
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Elevation of cytosolic Ca2+ levelsREACTOMER-HSA-139853

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
312326922019Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP.17
312326922019Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP.17
296744452018Druggable negative allosteric site of P2X3 receptors.34
296744452018Druggable negative allosteric site of P2X3 receptors.34
288982822017P2X3 receptor involvement in endometriosis pain via ERK signaling pathway.21
288982822017P2X3 receptor involvement in endometriosis pain via ERK signaling pathway.21
267389912016Upregulated P2X3 Receptor Expression in Patients with Intractable Temporal Lobe Epilepsy and in a Rat Model of Epilepsy.4
268253052016Inter-subunit disulfide locking of the human P2X3 receptor elucidates ectodomain movements associated with channel gating.1
271292812016Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies.11
273125482016Potential Involvement of P2 Receptors in the Pathological Processes of Hyperthyroidism: A Pilot Study.2
276263752016X-ray structures define human P2X(3) receptor gating cycle and antagonist action.120
267389912016Upregulated P2X3 Receptor Expression in Patients with Intractable Temporal Lobe Epilepsy and in a Rat Model of Epilepsy.4
268253052016Inter-subunit disulfide locking of the human P2X3 receptor elucidates ectodomain movements associated with channel gating.1
271292812016Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies.11
273125482016Potential Involvement of P2 Receptors in the Pathological Processes of Hyperthyroidism: A Pilot Study.2

Citation

Dessen P

P2RX3 (purinergic receptor P2X 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56601/js/favicon/manifest.json